Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1858708..1859510 Replicon chromosome
Accession NZ_CP094865
Organism Staphylococcus epidermidis strain C100

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUG64_RS08710 Protein ID WP_002469232.1
Coordinates 1859049..1859510 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUG64_RS08705 Protein ID WP_002439260.1
Coordinates 1858708..1859037 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG64_RS08655 (MUG64_08655) 1853751..1853966 + 216 WP_001831694.1 NINE protein -
MUG64_RS08660 (MUG64_08660) 1854508..1855038 + 531 WP_237625884.1 N-acetyltransferase -
MUG64_RS08665 (MUG64_08665) 1855274..1855471 + 198 WP_002456096.1 hypothetical protein -
MUG64_RS08670 (MUG64_08670) 1855812..1856045 - 234 Protein_1678 AAA family ATPase -
MUG64_RS08675 (MUG64_08675) 1856420..1856743 + 324 WP_002456098.1 hypothetical protein -
MUG64_RS12085 1856726..1856860 - 135 WP_002439268.1 hypothetical protein -
MUG64_RS08680 (MUG64_08680) 1856874..1857086 - 213 Protein_1681 DUF771 domain-containing protein -
MUG64_RS08685 (MUG64_08685) 1857090..1857854 - 765 WP_237625885.1 phage regulatory protein/antirepressor Ant -
MUG64_RS08690 (MUG64_08690) 1857904..1858110 + 207 WP_002439266.1 hypothetical protein -
MUG64_RS08695 (MUG64_08695) 1858099..1858263 - 165 WP_002439265.1 hypothetical protein -
MUG64_RS08700 (MUG64_08700) 1858260..1858514 - 255 WP_237625886.1 helix-turn-helix transcriptional regulator -
MUG64_RS08705 (MUG64_08705) 1858708..1859037 + 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
MUG64_RS08710 (MUG64_08710) 1859049..1859510 + 462 WP_002469232.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUG64_RS08715 (MUG64_08715) 1859526..1860044 + 519 WP_002439256.1 hypothetical protein -
MUG64_RS08720 (MUG64_08720) 1860046..1860489 + 444 WP_237625888.1 hypothetical protein -
MUG64_RS08725 (MUG64_08725) 1860562..1860756 + 195 WP_002439253.1 hypothetical protein -
MUG64_RS08730 (MUG64_08730) 1860825..1861340 + 516 WP_002439252.1 hypothetical protein -
MUG64_RS08735 (MUG64_08735) 1861342..1861677 + 336 WP_002439251.1 hypothetical protein -
MUG64_RS08740 (MUG64_08740) 1861733..1862131 + 399 Protein_1693 phage integrase SAM-like domain-containing protein -
MUG64_RS08745 (MUG64_08745) 1862237..1862797 + 561 WP_279594400.1 site-specific integrase -
MUG64_RS08760 (MUG64_08760) 1863303..1863878 - 576 WP_001829272.1 competence protein ComK -
MUG64_RS08765 (MUG64_08765) 1864093..1864311 + 219 WP_001829292.1 IDEAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1855800..1862797 6997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18327.03 Da        Isoelectric Point: 6.8511

>T240718 WP_002469232.1 NZ_CP094865:1859049-1859510 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYEAALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T240718 NZ_LT615378:c1927043-1926940 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT240718 WP_002439260.1 NZ_CP094865:1858708-1859037 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240718 NZ_LT615378:1926902-1927173 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References