Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1038351..1039153 Replicon chromosome
Accession NZ_CP094865
Organism Staphylococcus epidermidis strain C100

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MUG64_RS04995 Protein ID WP_002468490.1
Coordinates 1038974..1039153 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MUG64_RS04990 Protein ID WP_002456349.1
Coordinates 1038351..1038950 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG64_RS04965 (MUG64_04965) 1033563..1035020 + 1458 WP_237632665.1 ABC transporter substrate-binding protein/permease -
MUG64_RS04970 (MUG64_04970) 1035013..1035735 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MUG64_RS04975 (MUG64_04975) 1036232..1036381 + 150 WP_002468809.1 hypothetical protein -
MUG64_RS04980 (MUG64_04980) 1036596..1037726 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MUG64_RS04985 (MUG64_04985) 1037723..1038193 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUG64_RS04990 (MUG64_04990) 1038351..1038950 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MUG64_RS04995 (MUG64_04995) 1038974..1039153 + 180 WP_002468490.1 SAS053 family protein Toxin
MUG64_RS05000 (MUG64_05000) 1039309..1039713 + 405 WP_001829818.1 hypothetical protein -
MUG64_RS05005 (MUG64_05005) 1039898..1041283 + 1386 WP_001829862.1 class II fumarate hydratase -
MUG64_RS05010 (MUG64_05010) 1041644..1042468 - 825 WP_243932477.1 RluA family pseudouridine synthase -
MUG64_RS05015 (MUG64_05015) 1042627..1043760 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T240717 WP_002468490.1 NZ_CP094865:1038974-1039153 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T240717 NZ_LT615378:c1649287-1649000 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT240717 WP_002456349.1 NZ_CP094865:1038351-1038950 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT240717 NZ_LT615378:c1649526-1649287 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References