Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2001562..2002032 Replicon chromosome
Accession NZ_CP094859
Organism Staphylococcus epidermidis strain C99

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MUB20_RS09470 Protein ID WP_001829569.1
Coordinates 2001844..2002032 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MUB20_RS09465 Protein ID WP_002438963.1
Coordinates 2001562..2001819 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB20_RS09425 (MUB20_09425) 1996926..1997642 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MUB20_RS09430 (MUB20_09430) 1997803..1998225 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MUB20_RS09435 (MUB20_09435) 1998409..1998546 - 138 WP_162161215.1 hypothetical protein -
MUB20_RS09440 (MUB20_09440) 1998576..1998763 - 188 Protein_1836 hypothetical protein -
MUB20_RS09445 (MUB20_09445) 1999150..1999650 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MUB20_RS09450 (MUB20_09450) 1999921..2000508 - 588 WP_001829615.1 histidine phosphatase family protein -
MUB20_RS09455 (MUB20_09455) 2000722..2000958 + 237 WP_002457224.1 hypothetical protein -
MUB20_RS09460 (MUB20_09460) 2000950..2001153 - 204 WP_001829671.1 sterile alpha motif-like domain-containing protein -
MUB20_RS09465 (MUB20_09465) 2001562..2001819 + 258 WP_002438963.1 hypothetical protein Antitoxin
MUB20_RS09470 (MUB20_09470) 2001844..2002032 + 189 WP_001829569.1 hypothetical protein Toxin
MUB20_RS09475 (MUB20_09475) 2002222..2002776 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MUB20_RS09480 (MUB20_09480) 2002836..2003069 - 234 WP_001829664.1 hypothetical protein -
MUB20_RS09485 (MUB20_09485) 2003354..2004100 + 747 WP_001829580.1 poly-gamma-glutamate hydrolase family protein -
MUB20_RS09490 (MUB20_09490) 2004199..2004483 + 285 WP_001829635.1 hypothetical protein -
MUB20_RS09495 (MUB20_09495) 2004507..2004731 + 225 WP_001829613.1 hypothetical protein -
MUB20_RS09500 (MUB20_09500) 2005352..2005552 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1998409..1998564 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T240714 WP_001829569.1 NZ_CP094859:2001844-2002032 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T240714 NZ_LT615378:c1297765-1297658 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT240714 WP_002438963.1 NZ_CP094859:2001562-2001819 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT240714 NZ_LT615378:1297812-1297878 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References