240713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1860270..1861072 Replicon chromosome
Accession NZ_CP094859
Organism Staphylococcus epidermidis strain C99

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUB20_RS08720 Protein ID WP_002469232.1
Coordinates 1860611..1861072 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUB20_RS08715 Protein ID WP_002439260.1
Coordinates 1860270..1860599 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB20_RS08665 (MUB20_08665) 1855314..1855529 + 216 WP_001831694.1 NINE protein -
MUB20_RS08670 (MUB20_08670) 1856070..1856600 + 531 WP_237625884.1 N-acetyltransferase -
MUB20_RS08675 (MUB20_08675) 1856836..1857033 + 198 WP_002456096.1 hypothetical protein -
MUB20_RS08680 (MUB20_08680) 1857374..1857607 - 234 Protein_1683 AAA family ATPase -
MUB20_RS08685 (MUB20_08685) 1857937..1858305 + 369 WP_230372882.1 hypothetical protein -
MUB20_RS12090 1858288..1858422 - 135 WP_002439268.1 hypothetical protein -
MUB20_RS08690 (MUB20_08690) 1858436..1858648 - 213 Protein_1686 DUF771 domain-containing protein -
MUB20_RS08695 (MUB20_08695) 1858652..1859416 - 765 WP_237625885.1 phage regulatory protein/antirepressor Ant -
MUB20_RS08700 (MUB20_08700) 1859466..1859672 + 207 WP_002439266.1 hypothetical protein -
MUB20_RS08705 (MUB20_08705) 1859661..1859825 - 165 WP_002439265.1 hypothetical protein -
MUB20_RS08710 (MUB20_08710) 1859822..1860076 - 255 WP_237625886.1 helix-turn-helix transcriptional regulator -
MUB20_RS08715 (MUB20_08715) 1860270..1860599 + 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
MUB20_RS08720 (MUB20_08720) 1860611..1861072 + 462 WP_002469232.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUB20_RS08725 (MUB20_08725) 1861088..1861606 + 519 WP_002439256.1 hypothetical protein -
MUB20_RS08730 (MUB20_08730) 1861608..1862051 + 444 WP_237625888.1 hypothetical protein -
MUB20_RS08735 (MUB20_08735) 1862124..1862318 + 195 WP_002439253.1 hypothetical protein -
MUB20_RS08740 (MUB20_08740) 1862387..1862902 + 516 WP_002439252.1 hypothetical protein -
MUB20_RS08745 (MUB20_08745) 1862904..1863239 + 336 WP_002439251.1 hypothetical protein -
MUB20_RS08750 (MUB20_08750) 1863295..1863693 + 399 Protein_1698 phage integrase SAM-like domain-containing protein -
MUB20_RS08755 (MUB20_08755) 1863799..1864359 + 561 WP_279594400.1 site-specific integrase -
MUB20_RS08770 (MUB20_08770) 1864865..1865440 - 576 WP_001829272.1 competence protein ComK -
MUB20_RS08775 (MUB20_08775) 1865655..1865873 + 219 WP_001829292.1 IDEAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1854526..1864359 9833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18327.03 Da        Isoelectric Point: 6.8511

>T240713 WP_002469232.1 NZ_CP094859:1860611-1861072 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYEAALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T240713 NZ_LT615378:c1297230-1297123 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT240713 WP_002439260.1 NZ_CP094859:1860270-1860599 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240713 NZ_LT615378:1297277-1297343 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References