Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1039725..1040527 Replicon chromosome
Accession NZ_CP094859
Organism Staphylococcus epidermidis strain C99

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MUB20_RS05000 Protein ID WP_002468490.1
Coordinates 1040348..1040527 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MUB20_RS04995 Protein ID WP_002456349.1
Coordinates 1039725..1040324 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB20_RS04975 (MUB20_04975) 1034937..1036394 + 1458 WP_237632665.1 ABC transporter substrate-binding protein/permease -
MUB20_RS04980 (MUB20_04980) 1036387..1037109 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MUB20_RS12080 1037624..1037755 + 132 WP_255264851.1 hypothetical protein -
MUB20_RS04985 (MUB20_04985) 1037970..1039100 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MUB20_RS04990 (MUB20_04990) 1039097..1039567 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUB20_RS04995 (MUB20_04995) 1039725..1040324 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MUB20_RS05000 (MUB20_05000) 1040348..1040527 + 180 WP_002468490.1 SAS053 family protein Toxin
MUB20_RS05005 (MUB20_05005) 1040683..1041087 + 405 WP_001829818.1 hypothetical protein -
MUB20_RS05010 (MUB20_05010) 1041272..1042657 + 1386 WP_001829862.1 class II fumarate hydratase -
MUB20_RS05015 (MUB20_05015) 1043018..1043842 - 825 WP_243932477.1 RluA family pseudouridine synthase -
MUB20_RS05020 (MUB20_05020) 1044001..1045134 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T240712 WP_002468490.1 NZ_CP094859:1040348-1040527 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T240712 NZ_LT615378:c1296695-1296588 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT240712 WP_002456349.1 NZ_CP094859:1039725-1040324 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT240712 NZ_LT615378:1296743-1296809 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References