Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 863665..864174 Replicon chromosome
Accession NZ_CP094859
Organism Staphylococcus epidermidis strain C99

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MUB20_RS03985 Protein ID WP_001829980.1
Coordinates 863965..864174 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MUB20_RS03980 Protein ID WP_001829893.1
Coordinates 863665..863958 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB20_RS03955 (MUB20_03955) 858673..859461 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MUB20_RS03960 (MUB20_03960) 859467..860105 + 639 WP_002505076.1 thiamine phosphate synthase -
MUB20_RS03965 (MUB20_03965) 860194..861066 + 873 WP_002458703.1 membrane protein insertase YidC -
MUB20_RS03970 (MUB20_03970) 861172..861825 - 654 WP_001829983.1 HD domain-containing protein -
MUB20_RS03975 (MUB20_03975) 862007..863491 - 1485 WP_002457116.1 cardiolipin synthase -
MUB20_RS03980 (MUB20_03980) 863665..863958 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUB20_RS03985 (MUB20_03985) 863965..864174 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MUB20_RS03990 (MUB20_03990) 864317..864454 + 138 WP_001829949.1 Lmo0850 family protein -
MUB20_RS03995 (MUB20_03995) 864554..865765 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MUB20_RS04000 (MUB20_04000) 866156..867229 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MUB20_RS04005 (MUB20_04005) 867241..868596 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T240710 WP_001829980.1 NZ_CP094859:863965-864174 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T240710 NZ_LT615378:c263061-262720 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT240710 WP_001829893.1 NZ_CP094859:863665-863958 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT240710 NZ_LT615378:c263399-263082 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References