240703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2101563..2102077 Replicon chromosome
Accession NZ_CP094857
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MTX75_RS10425 Protein ID WP_000581792.1
Coordinates 2101563..2101772 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MTX75_RS10430 Protein ID WP_000138932.1
Coordinates 2101784..2102077 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX75_RS10405 (2097071) 2097071..2098429 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MTX75_RS10410 (2098444) 2098444..2099514 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MTX75_RS10415 (2099832) 2099832..2101034 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MTX75_RS10420 (2101298) 2101298..2101435 - 138 WP_000828354.1 Lmo0850 family protein -
MTX75_RS10425 (2101563) 2101563..2101772 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MTX75_RS10430 (2101784) 2101784..2102077 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MTX75_RS10435 (2102243) 2102243..2103727 + 1485 WP_000571549.1 cardiolipin synthase -
MTX75_RS10440 (2103755) 2103755..2104402 + 648 WP_001187630.1 HD domain-containing protein -
MTX75_RS10445 (2105315) 2105315..2106187 - 873 WP_000725802.1 membrane protein insertase YidC -
MTX75_RS10450 (2106273) 2106273..2106914 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240703 WP_000581792.1 NZ_CP094857:c2101772-2101563 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240703 NZ_LT615377:3273849-3274313 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240703 WP_000138932.1 NZ_CP094857:c2102077-2101784 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240703 NZ_LT615377:3273514-3273849 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References