Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3766634..3767163 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag TBMG_RS17725 Protein ID WP_003417760.1
Coordinates 3766906..3767163 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag TBMG_RS17720 Protein ID WP_003417757.1
Coordinates 3766634..3766909 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS22610 3763432..3764869 - 1438 Protein_3463 FAD-binding oxidoreductase -
TBMG_RS17705 3764972..3765361 + 390 WP_003417745.1 DUF732 domain-containing protein -
TBMG_RS17710 3765375..3765668 - 294 WP_003417749.1 DUF3017 domain-containing protein -
TBMG_RS17715 3765665..3766510 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
TBMG_RS17720 3766634..3766909 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
TBMG_RS17725 3766906..3767163 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
TBMG_RS17730 3767205..3768395 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
TBMG_RS17735 3768512..3768880 + 369 WP_003417765.1 FHA domain-containing protein -
TBMG_RS17740 3768877..3769428 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
TBMG_RS17745 3769435..3770016 - 582 WP_003417769.1 ATP/GTP-binding protein -
TBMG_RS17750 3769997..3770365 - 369 WP_003417772.1 DUF742 domain-containing protein -
TBMG_RS17755 3770343..3770735 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T24069 WP_003417760.1 NC_012943:3766906-3767163 [Mycobacterium tuberculosis KZN 1435]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T24069 NC_012943:3766906-3767163 [Mycobacterium tuberculosis KZN 1435]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT24069 WP_003417757.1 NC_012943:3766634-3766909 [Mycobacterium tuberculosis KZN 1435]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT24069 NC_012943:3766634-3766909 [Mycobacterium tuberculosis KZN 1435]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References