240683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2189660..2190137 Replicon chromosome
Accession NZ_CP094855
Organism Staphylococcus aureus strain NY2491

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag MTX64_RS11080 Protein ID WP_000052078.1
Coordinates 2189949..2190137 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MTX64_RS11075 Protein ID WP_001059690.1
Coordinates 2189660..2189920 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX64_RS11040 (2185053) 2185053..2185769 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
MTX64_RS11045 (2185917) 2185917..2186339 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
MTX64_RS11050 (2186738) 2186738..2187232 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
MTX64_RS11055 (2187387) 2187387..2188004 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
MTX64_RS11060 (2188077) 2188077..2188658 - 582 WP_001140685.1 histidine phosphatase family protein -
MTX64_RS11065 (2188883) 2188883..2189119 + 237 WP_000368687.1 hypothetical protein -
MTX64_RS11070 (2189116) 2189116..2189319 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MTX64_RS11075 (2189660) 2189660..2189920 + 261 WP_001059690.1 hypothetical protein Antitoxin
MTX64_RS11080 (2189949) 2189949..2190137 + 189 WP_000052078.1 hypothetical protein Toxin
MTX64_RS11085 (2190325) 2190325..2190894 + 570 WP_001106644.1 lipoprotein N-acylation protein LnsA -
MTX64_RS11090 (2190982) 2190982..2191266 + 285 WP_001004395.1 hypothetical protein -
MTX64_RS11095 (2191328) 2191328..2191546 + 219 WP_000005886.1 hypothetical protein -
MTX64_RS11100 (2192042) 2192042..2192242 - 201 WP_001059082.1 cold-shock protein -
MTX64_RS11105 (2192599) 2192599..2193285 - 687 WP_001548082.1 thermonuclease family protein -
MTX64_RS11110 (2193626) 2193626..2194096 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / selq / selk 2106141..2195453 89312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(76-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T240683 WP_000052078.1 NZ_CP094855:2189949-2190137 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240683 NZ_LT615367:c3365858-3365364 [Dickeya aquatica]
ATGATCTCTGCCCCTGAGCCACTCCACGCCGAACATGTACTTTCCTCATTCTGTTGCGGCGTGGAGTCTATGGATAACTG
GCTAAAACTACGGGCGATGAAAAATCAGGTCACTGGCGCATCACGAACTTTCGTCAGTTGCGATGGCTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGTGCTGTAGCAACGAATGTCGCTCCCGGACGCTTTCGCCGCAATATGCCTGATCCGATC
CCGGTGGTGGTGCTGGGGCGTCTGGCGGTAGATAAATCATTACATGGTCAGGGTGTTGGCCGAGCGCTGGTGCGCGATGC
CGGGCTGCGGGTGATTCAGGTGGCGGATACCATCGGTATTCGCGGGATGTTGGTTCATGCGCTGTCTGATGAAGCGCGGG
AATTTTACCTGCGGGTGGGGTTTGAACCTTCGCCGATCGATCCGATGATATTGATGGTGACGCTGGGGGATTTGGTGGGG
AGTTTATCAATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240683 WP_001059690.1 NZ_CP094855:2189660-2189920 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240683 NZ_LT615367:c3366148-3365855 [Dickeya aquatica]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACACTAAATTTACGCATCAAACCCGCCGAACGCGATCTTATCGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGTACTGATTTTGTTCTTGAGGCTGCTCGCGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCGTCATGGCAGATCCTGATGCTTATCAGGAATTCCTCGTTCGTTTGGATCAGGCCCCTTCCCCGAAT
GCCGCGCTGCGAAAAACCATGCAAACCCCCGCACCGTGGGAACAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References