Detailed information of TA system TA240682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2172047..2172579
• Replicon: chromosome
• Accession: NZ_CP094855
• Organism: Staphylococcus aureus strain NY2491

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: MTX64_RS10935
• Protein ID: WP_001103942.1
• Coordinates: 2172047..2172367 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MTX64_RS10940
• Protein ID: WP_001058486.1
• Coordinates: 2172370..2172579 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX64_RS10910 (2167185)	2167185..2167526	-	342	WP_001190605.1	hypothetical protein	-
MTX64_RS10915 (2168062)	2168062..2168703	-	642	WP_001019597.1	hypothetical protein	-
MTX64_RS10920 (2168700)	2168700..2169080	-	381	WP_000356943.1	hypothetical protein	-
MTX64_RS10925 (2169391)	2169391..2171100	-	1710	WP_000447445.1	DUF927 domain-containing protein	-
MTX64_RS10930 (2171114)	2171114..2171983	-	870	WP_001002729.1	primase alpha helix C-terminal domain-containing protein	-
MTX64_RS10935 (2172047)	2172047..2172367	-	321	WP_001103942.1	DUF1474 family protein	Toxin
MTX64_RS10940 (2172370)	2172370..2172579	-	210	WP_001058486.1	hypothetical protein	Antitoxin
MTX64_RS10945 (2172572)	2172572..2172718	-	147	WP_000784875.1	hypothetical protein	-
MTX64_RS10950 (2172730)	2172730..2173002	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
MTX64_RS10955 (2172995)	2172995..2173258	-	264	WP_000243851.1	helix-turn-helix transcriptional regulator	-
MTX64_RS10960 (2173451)	2173451..2173783	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
MTX64_RS10965 (2173795)	2173795..2174253	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
MTX64_RS10970 (2174270)	2174270..2174701	+	432	WP_001228759.1	hypothetical protein	-
MTX64_RS10975 (2174771)	2174771..2175499	+	729	WP_001033319.1	staphylococcal enterotoxin type Q	-
MTX64_RS10980 (2175523)	2175523..2176251	+	729	WP_000733773.1	staphylococcal enterotoxin type K	-
MTX64_RS10985 (2176339)	2176339..2177559	+	1221	WP_000264182.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / selq / selk	2106141..2195453	89312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T240682 WP_001103942.1 NZ_CP094855:c2172367-2172047 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T240682 NZ_LT615367:3153694-3153897 [Dickeya aquatica]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGGAAATGCACAACTATCGATACTCTCGAACGCGTTATAGAGAAAAACAA
ATACGAGCTCTCTAATGACGAACTCGAAATGTTTTATTCTGCGGCAGATCATCGACTTGCCGAGCTAACGATGAATAAAC
TTTACGACAAAGTACCAACCGCGGTCTGGAAATACGTTCGTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT240682 WP_001058486.1 NZ_CP094855:c2172579-2172370 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240682 NZ_LT615367:3153273-3153641 [Dickeya aquatica]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGATGAGAGTATCGC
AACATTAGGCGATAGCAGCCACGGTTGGGTTAATGATCCAACATCAGCGGTCAATCTCCAGTTGAATGAGCTTATTGAGC
ATATTGCCGCATTTGTCGTTACCTATAAAATTAAATACCCTCACGAGAGTGGATTATGTGAACGGGTTGAAAAATATCTC
GACGATACTTATATTCTTTTCAGTAACTACGGTATAAACGACACCGAGTTACAGAAATGGCAAAAATCCAAGTCCCAATT
ATTCAGAATGTTCTCAGAAAAGAACGTCTGTACAGTAGTAAAAACTTAA

Structures

Toxin

• AlphaFold DB: Q93CD4