Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3705699..3706373 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag TBMG_RS17535 Protein ID WP_003417282.1
Coordinates 3705699..3706127 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag TBMG_RS17540 Protein ID WP_003417286.1
Coordinates 3706131..3706373 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS17510 3701521..3701922 - 402 WP_003417264.1 cytidine deaminase -
TBMG_RS17515 3702063..3702497 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
TBMG_RS17520 3702494..3702928 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
TBMG_RS17525 3703057..3704829 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
TBMG_RS17530 3704829..3705620 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
TBMG_RS17535 3705699..3706127 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
TBMG_RS17540 3706131..3706373 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
TBMG_RS17545 3706495..3707109 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
TBMG_RS17550 3707106..3707771 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
TBMG_RS17555 3707772..3708305 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
TBMG_RS17560 3708302..3708676 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
TBMG_RS17575 3710050..3710241 - 192 Protein_3440 RNA polymerase sigma factor SigJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T24068 WP_003417282.1 NC_012943:c3706127-3705699 [Mycobacterium tuberculosis KZN 1435]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T24068 NC_012943:c3706127-3705699 [Mycobacterium tuberculosis KZN 1435]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT24068 WP_003417286.1 NC_012943:c3706373-3706131 [Mycobacterium tuberculosis KZN 1435]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT24068 NC_012943:c3706373-3706131 [Mycobacterium tuberculosis KZN 1435]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References