Detailed information of TA system TA240677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2004662..2005438
• Replicon: chromosome
• Accession: NZ_CP094855
• Organism: Staphylococcus aureus strain NY2491

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MTX64_RS09840
• Protein ID: WP_000031108.1
• Coordinates: 2004662..2004814 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MTX64_RS09845
• Protein ID: WP_001251224.1
• Coordinates: 2004839..2005438 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX64_RS09825 (2000625)	2000625..2001446	+	822	WP_000669375.1	RluA family pseudouridine synthase	-
MTX64_RS09830 (2001909)	2001909..2003294	-	1386	WP_000116224.1	class II fumarate hydratase	-
MTX64_RS09835 (2003490)	2003490..2003885	-	396	WP_000901021.1	hypothetical protein	-
MTX64_RS09840 (2004662)	2004662..2004814	-	153	WP_000031108.1	SAS053 family protein	Toxin
MTX64_RS09845 (2004839)	2004839..2005438	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MTX64_RS09850 (2005597)	2005597..2006067	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MTX64_RS09855 (2006072)	2006072..2007199	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
MTX64_RS09860 (2007350)	2007350..2008072	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MTX64_RS09865 (2008065)	2008065..2009522	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T240677 WP_000031108.1 NZ_CP094855:c2004814-2004662 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240677 NZ_LT615367:528446-528721 [Dickeya aquatica]
ATGGAAATACTTTGGACACAAAAGGCACAGGATGACCTAGAGCGCATTTATCGGTTTGCCAGCCAGTACAGTCGGCAGCA
TGCTGACGATGTGTTAGATCGCCTGTTCATCGGAACAACAGAGCTTGTTGATCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAACCCCGTGAGGTGAGAAAAATTCTGTTTGATGATTACGAGGTTCACTATGAAATTCAGCACAACACTATTTAT
ATCGTCGATTTGTGGCATACACGAGAAGATCGCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT240677 WP_001251224.1 NZ_CP094855:c2005438-2004839 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240677 NZ_LT615367:528194-528442 [Dickeya aquatica]
ATGGGACAGCCCGCAAAACAGACTATTAGTGCTCAGATACCCGCCGAGCTTGCTGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGGTCGAAAAGTTGGGTGATTAAAGAAGCATTGACCGCAATGATCGAAGAGAGAGAACGTCAGCATCAACGGA
TTTTGCAAGGCCTTGCTGATGTTGATGCTGGAAGGGTGGTAAACCATGCTGATGTTCTCGATTTTGCCAATAAACTGAAA
AAGTCGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4