240667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2244329..2244843 Replicon chromosome
Accession NZ_CP094853
Organism Staphylococcus aureus strain NY2010

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MTX62_RS11295 Protein ID WP_000581792.1
Coordinates 2244329..2244538 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MTX62_RS11300 Protein ID WP_000138932.1
Coordinates 2244550..2244843 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX62_RS11275 (2239837) 2239837..2241195 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MTX62_RS11280 (2241210) 2241210..2242280 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MTX62_RS11285 (2242598) 2242598..2243800 + 1203 WP_009560675.1 FtsW/RodA/SpoVE family cell cycle protein -
MTX62_RS11290 (2244064) 2244064..2244201 - 138 WP_000828354.1 Lmo0850 family protein -
MTX62_RS11295 (2244329) 2244329..2244538 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MTX62_RS11300 (2244550) 2244550..2244843 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MTX62_RS11305 (2245009) 2245009..2246493 + 1485 WP_000571549.1 cardiolipin synthase -
MTX62_RS11310 (2246521) 2246521..2247167 + 647 Protein_2197 HD domain-containing protein -
MTX62_RS11315 (2247980) 2247980..2248852 - 873 WP_000725802.1 membrane protein insertase YidC -
MTX62_RS11320 (2248938) 2248938..2249579 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240667 WP_000581792.1 NZ_CP094853:c2244538-2244329 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240667 NZ_LT615218:c2016737-2016486 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240667 WP_000138932.1 NZ_CP094853:c2244843-2244550 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240667 NZ_LT615218:c2016496-2016323 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References