Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2224573..2225102 Replicon chromosome
Accession NZ_CP094853
Organism Staphylococcus aureus strain NY2010

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MTX62_RS11205 Protein ID WP_000621175.1
Coordinates 2224573..2224935 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MTX62_RS11210 Protein ID WP_000948331.1
Coordinates 2224932..2225102 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX62_RS11185 (2221552) 2221552..2222322 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
MTX62_RS11190 (2222297) 2222297..2222776 - 480 WP_001190829.1 anti-sigma B factor RsbW -
MTX62_RS11195 (2222778) 2222778..2223104 - 327 WP_001052491.1 anti-sigma factor antagonist -
MTX62_RS11200 (2223223) 2223223..2224224 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MTX62_RS11205 (2224573) 2224573..2224935 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MTX62_RS11210 (2224932) 2224932..2225102 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MTX62_RS11215 (2225187) 2225187..2226335 - 1149 WP_001281145.1 alanine racemase -
MTX62_RS11220 (2226401) 2226401..2226760 - 360 WP_000581200.1 holo-ACP synthase -
MTX62_RS11225 (2226764) 2226764..2227255 - 492 WP_001205910.1 PH domain-containing protein -
MTX62_RS11230 (2227242) 2227242..2228825 - 1584 WP_001294626.1 PH domain-containing protein -
MTX62_RS11235 (2228818) 2228818..2229297 - 480 WP_001287088.1 hypothetical protein -
MTX62_RS11240 (2229505) 2229505..2230065 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240666 WP_000621175.1 NZ_CP094853:c2224935-2224573 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240666 NZ_LT615218:c1991914-1991738 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240666 WP_000948331.1 NZ_CP094853:c2225102-2224932 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240666 NZ_LT615218:1991615-1991670 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References