Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2173102..2173607 | Replicon | chromosome |
| Accession | NZ_CP094853 | ||
| Organism | Staphylococcus aureus strain NY2010 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | - |
| Locus tag | MTX62_RS10935 | Protein ID | WP_001103948.1 |
| Coordinates | 2173102..2173395 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | X5IY59 |
| Locus tag | MTX62_RS10940 | Protein ID | WP_001058494.1 |
| Coordinates | 2173398..2173607 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTX62_RS10905 (2168310) | 2168310..2168651 | - | 342 | WP_001190605.1 | hypothetical protein | - |
| MTX62_RS10910 (2169096) | 2169096..2169724 | - | 629 | Protein_2122 | pathogenicity island protein | - |
| MTX62_RS10915 (2169721) | 2169721..2170005 | - | 285 | WP_000998180.1 | hypothetical protein | - |
| MTX62_RS10920 (2170007) | 2170007..2170369 | - | 363 | WP_001039167.1 | hypothetical protein | - |
| MTX62_RS10925 (2170671) | 2170671..2172128 | - | 1458 | WP_000432707.1 | virulence-associated E family protein | - |
| MTX62_RS10930 (2172145) | 2172145..2173014 | - | 870 | WP_001002692.1 | primase alpha helix C-terminal domain-containing protein | - |
| MTX62_RS10935 (2173102) | 2173102..2173395 | - | 294 | WP_001103948.1 | DUF1474 family protein | Toxin |
| MTX62_RS10940 (2173398) | 2173398..2173607 | - | 210 | WP_001058494.1 | hypothetical protein | Antitoxin |
| MTX62_RS10945 (2173600) | 2173600..2173746 | - | 147 | WP_000784885.1 | hypothetical protein | - |
| MTX62_RS10950 (2173743) | 2173743..2174060 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
| MTX62_RS10955 (2174065) | 2174065..2174283 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| MTX62_RS10960 (2174456) | 2174456..2175130 | + | 675 | WP_000620857.1 | helix-turn-helix transcriptional regulator | - |
| MTX62_RS10965 (2175144) | 2175144..2176316 | + | 1173 | WP_000179344.1 | tyrosine-type recombinase/integrase | - |
| MTX62_RS10970 (2176385) | 2176385..2178001 | - | 1617 | WP_000240653.1 | chaperonin GroEL | - |
| MTX62_RS10975 (2178077) | 2178077..2178361 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11576.05 Da Isoelectric Point: 4.9594
>T240665 WP_001103948.1 NZ_CP094853:c2173395-2173102 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSGSYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSGSYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA
Download Length: 294 bp
>T240665 NZ_LT615218:c1890817-1890665 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8268.31 Da Isoelectric Point: 4.3718
>AT240665 WP_001058494.1 NZ_CP094853:c2173607-2173398 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT240665 NZ_LT615218:c1891441-1890842 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|