Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2145115..2145592 Replicon chromosome
Accession NZ_CP094853
Organism Staphylococcus aureus strain NY2010

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag MTX62_RS10775 Protein ID WP_000052078.1
Coordinates 2145404..2145592 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MTX62_RS10770 Protein ID WP_001059690.1
Coordinates 2145115..2145375 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX62_RS10735 (2140508) 2140508..2141224 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
MTX62_RS10740 (2141372) 2141372..2141794 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
MTX62_RS10745 (2142193) 2142193..2142687 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
MTX62_RS10750 (2142842) 2142842..2143459 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
MTX62_RS10755 (2143532) 2143532..2144113 - 582 WP_001140685.1 histidine phosphatase family protein -
MTX62_RS10760 (2144338) 2144338..2144574 + 237 WP_000368687.1 hypothetical protein -
MTX62_RS10765 (2144571) 2144571..2144774 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MTX62_RS10770 (2145115) 2145115..2145375 + 261 WP_001059690.1 hypothetical protein Antitoxin
MTX62_RS10775 (2145404) 2145404..2145592 + 189 WP_000052078.1 hypothetical protein Toxin
MTX62_RS10780 (2145780) 2145780..2146349 + 570 WP_001106644.1 lipoprotein N-acylation protein LnsA -
MTX62_RS10785 (2146437) 2146437..2146721 + 285 WP_001004395.1 hypothetical protein -
MTX62_RS10790 (2146783) 2146783..2147001 + 219 WP_000005886.1 hypothetical protein -
MTX62_RS10795 (2147497) 2147497..2147697 - 201 WP_001059082.1 cold-shock protein -
MTX62_RS10800 (2148054) 2148054..2148740 - 687 WP_001548082.1 thermonuclease family protein -
MTX62_RS10805 (2149081) 2149081..2149551 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / selq / selk 2061602..2150908 89306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T240664 WP_000052078.1 NZ_CP094853:2145404-2145592 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240664 NZ_LT615218:c861679-861491 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240664 WP_001059690.1 NZ_CP094853:2145115-2145375 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240664 NZ_LT615218:c861968-861708 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References