Detailed information of TA system TA240663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2127502..2128034
• Replicon: chromosome
• Accession: NZ_CP094853
• Organism: Staphylococcus aureus strain NY2010

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: MTX62_RS10630
• Protein ID: WP_001103942.1
• Coordinates: 2127502..2127822 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MTX62_RS10635
• Protein ID: WP_001058486.1
• Coordinates: 2127825..2128034 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX62_RS10605 (2122640)	2122640..2122981	-	342	WP_001190605.1	hypothetical protein	-
MTX62_RS10610 (2123517)	2123517..2124158	-	642	WP_001019597.1	hypothetical protein	-
MTX62_RS10615 (2124155)	2124155..2124535	-	381	WP_000356943.1	hypothetical protein	-
MTX62_RS10620 (2124846)	2124846..2126555	-	1710	WP_000447445.1	DUF927 domain-containing protein	-
MTX62_RS10625 (2126569)	2126569..2127438	-	870	WP_001002729.1	primase alpha helix C-terminal domain-containing protein	-
MTX62_RS10630 (2127502)	2127502..2127822	-	321	WP_001103942.1	DUF1474 family protein	Toxin
MTX62_RS10635 (2127825)	2127825..2128034	-	210	WP_001058486.1	hypothetical protein	Antitoxin
MTX62_RS10640 (2128027)	2128027..2128173	-	147	WP_000784875.1	hypothetical protein	-
MTX62_RS10645 (2128185)	2128185..2128457	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
MTX62_RS10650 (2128450)	2128450..2128713	-	264	WP_000243851.1	helix-turn-helix transcriptional regulator	-
MTX62_RS10655 (2128906)	2128906..2129238	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
MTX62_RS10660 (2129250)	2129250..2129708	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
MTX62_RS10665 (2129725)	2129725..2130156	+	432	WP_001228759.1	hypothetical protein	-
MTX62_RS10670 (2130226)	2130226..2130954	+	729	WP_001033319.1	staphylococcal enterotoxin type Q	-
MTX62_RS10675 (2130978)	2130978..2131706	+	729	WP_000733773.1	staphylococcal enterotoxin type K	-
MTX62_RS10680 (2131794)	2131794..2133014	+	1221	WP_000264182.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / selq / selk	2061602..2150908	89306

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T240663 WP_001103942.1 NZ_CP094853:c2127822-2127502 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T240663 NZ_LT615218:807395-807646 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGTATTATGGTAAGTCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT240663 WP_001058486.1 NZ_CP094853:c2128034-2127825 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240663 NZ_LT615218:807636-807809 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Structures

Toxin

• AlphaFold DB: Q93CD4