Detailed information of TA system TA240658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1960117..1960893
• Replicon: chromosome
• Accession: NZ_CP094853
• Organism: Staphylococcus aureus strain NY2010

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MTX62_RS09525
• Protein ID: WP_000031108.1
• Coordinates: 1960117..1960269 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MTX62_RS09530
• Protein ID: WP_001251224.1
• Coordinates: 1960294..1960893 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX62_RS09510 (1956080)	1956080..1956901	+	822	WP_000669375.1	RluA family pseudouridine synthase	-
MTX62_RS09515 (1957364)	1957364..1958749	-	1386	WP_000116224.1	class II fumarate hydratase	-
MTX62_RS09520 (1958945)	1958945..1959340	-	396	WP_000901021.1	hypothetical protein	-
MTX62_RS09525 (1960117)	1960117..1960269	-	153	WP_000031108.1	SAS053 family protein	Toxin
MTX62_RS09530 (1960294)	1960294..1960893	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MTX62_RS09535 (1961052)	1961052..1961522	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MTX62_RS09540 (1961527)	1961527..1962654	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
MTX62_RS09545 (1962805)	1962805..1963527	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MTX62_RS09550 (1963520)	1963520..1964977	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T240658 WP_000031108.1 NZ_CP094853:c1960269-1960117 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240658 NZ_LT608330:279205-279531 [Pseudomonas aeruginosa]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCGCGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT240658 WP_001251224.1 NZ_CP094853:c1960893-1960294 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240658 NZ_LT608330:278606-279133 [Pseudomonas aeruginosa]
ATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCACGCTGATCAAACTGCTGTACCTGGCAGACCG
AGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTTCCATGCCCCATGGGCCTGTCCTTTCCTCGA
CGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGGATTTCTCCGTTGGTGGATCACGAGGTCCGT
CTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATCGGATCGCAGCATTTTGGAATCGGTCTGGCA
AGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATCACATTGGTGAGTGGCACGACCCCCACGGCT
CTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGCGAGGAGCTGGCGGAGATCAAGGCGCGCGAT
CTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4