Detailed information of TA system TA240652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3517369..3518590
• Replicon: chromosome
• Accession: NZ_CP094851
• Organism: Pseudomonas aeruginosa strain R20-14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MUG61_RS16025
• Protein ID: WP_003102740.1
• Coordinates: 3518012..3518590 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MUG61_RS16020
• Protein ID: WP_003088112.1
• Coordinates: 3517369..3517923 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T240652 WP_003102740.1 NZ_CP094851:3518012-3518590 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T240652 NZ_LT606946:437324-437602 [Polynucleobacter necessarius]
ATGGATTTTGAATGGGATATGGCTAAAAGTGATTTATGCCAGATCTCTCGAAATTTCGATTTCACATATGTAGTATCAGT
TTTCATAGATCTGAATTTGTTGATAGAAAGAGATCAGCGTTGGGATTACGGGGAAGAGCGATTTCGGGCATTGGGTTTGC
TGTCCGAAAAAGTATTTGTAGTGATTTATACAAAGAGGCCTGCAGCAATTAGGATTATTTCAGCTAGGCGGGCAAATCGT
AGGGAGGTGAGGCGTTATGAAGAAAATCATTCGAGTTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT240652 WP_003088112.1 NZ_CP094851:3517369-3517923 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT240652 NZ_LT606946:437718-437921 [Polynucleobacter necessarius]
ATGTTGGATGCCGCTCAATATGCAAAAGGTGTGCGCGAGAGAATTGGTTTATCTCAGCAAGAGTTCTCTAAGCGCATCGA
AGTCTCTCTAGAAACCATTCGAAATTGGGAGCAAGGTAAACGCAGTCCCACTGGTGCAGCTAAAGCTTTGTTGAAAATTT
TAGATAGAGCGCCTGAGATAGCATTGTTGGCTCTCAGCGTTTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07