Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 140940..141445 | Replicon | chromosome |
| Accession | NZ_CP094851 | ||
| Organism | Pseudomonas aeruginosa strain R20-14 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | V6A7K8 |
| Locus tag | MUG61_RS00640 | Protein ID | WP_003083773.1 |
| Coordinates | 140940..141221 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9I707 |
| Locus tag | MUG61_RS00645 | Protein ID | WP_003112628.1 |
| Coordinates | 141218..141445 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUG61_RS00615 (MUG61_00615) | 136191..137540 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
| MUG61_RS00620 (MUG61_00620) | 137589..138275 | + | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
| MUG61_RS00625 (MUG61_00625) | 138376..139110 | + | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
| MUG61_RS00630 (MUG61_00630) | 139290..139700 | + | 411 | WP_003101225.1 | aegerolysin family protein | - |
| MUG61_RS00635 (MUG61_00635) | 139732..140640 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
| MUG61_RS00640 (MUG61_00640) | 140940..141221 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
| MUG61_RS00645 (MUG61_00645) | 141218..141445 | - | 228 | WP_003112628.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| MUG61_RS00650 (MUG61_00650) | 141621..142241 | - | 621 | WP_003101226.1 | hypothetical protein | - |
| MUG61_RS00655 (MUG61_00655) | 142342..142842 | + | 501 | WP_033969777.1 | LEA type 2 family protein | - |
| MUG61_RS00660 (MUG61_00660) | 142915..143256 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
| MUG61_RS00665 (MUG61_00665) | 143338..144765 | - | 1428 | WP_003083784.1 | GABA permease | - |
| MUG61_RS00670 (MUG61_00670) | 144934..146427 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T240650 WP_003083773.1 NZ_CP094851:c141221-140940 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T240650 NZ_LT606946:161416-161904 [Polynucleobacter necessarius]
ATGAGTGTTCAGGTCGTTTGGAGAATTGCATTGGATGCGCCCACGTTTAAGGCGGATGATCTCAGTGGCGAAGGGGCAAA
AAAATCAGGCGGGAGATGGAATAAAAAAGGGACACCTGTTCTCTATACCTCTGAATCGATTGCCCTTGCTTGTTTAGAGA
CCTTAGTGCATATCAATGCACAAGGCCTTCCCTTAAATCGCTATTTAGTGCGCATTGATATCCCAACAAAAGTATGGGAC
ATGGCTAAGAAATTCAATTTCAAAACTGCTGGATTCGGTTGGGATGCTTTACCGGCAGGAACAGTGAGTATTGATAAAGG
TGAGAAGTGGCTGCAATCCAATGCGAGTGCTTTACTCTTTGTACCTTCAGTGGTCATACCGCAAGCAAGTAACGTATTGA
TTAATCCCTTACATCCGGATACAAAGCTGATCAAGGCTAAGAAAATTGAGAAATTTTCTTATGACCCTCGTTTAGTGAGT
CTGCCTTAA
ATGAGTGTTCAGGTCGTTTGGAGAATTGCATTGGATGCGCCCACGTTTAAGGCGGATGATCTCAGTGGCGAAGGGGCAAA
AAAATCAGGCGGGAGATGGAATAAAAAAGGGACACCTGTTCTCTATACCTCTGAATCGATTGCCCTTGCTTGTTTAGAGA
CCTTAGTGCATATCAATGCACAAGGCCTTCCCTTAAATCGCTATTTAGTGCGCATTGATATCCCAACAAAAGTATGGGAC
ATGGCTAAGAAATTCAATTTCAAAACTGCTGGATTCGGTTGGGATGCTTTACCGGCAGGAACAGTGAGTATTGATAAAGG
TGAGAAGTGGCTGCAATCCAATGCGAGTGCTTTACTCTTTGTACCTTCAGTGGTCATACCGCAAGCAAGTAACGTATTGA
TTAATCCCTTACATCCGGATACAAAGCTGATCAAGGCTAAGAAAATTGAGAAATTTTCTTATGACCCTCGTTTAGTGAGT
CTGCCTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT240650 WP_003112628.1 NZ_CP094851:c141445-141218 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
Download Length: 228 bp
>AT240650 NZ_LT606946:160919-161419 [Polynucleobacter necessarius]
ATGTCTAGTGTCATCGCCAAAAAGCCCGGCACAAAAGTGACTCGCAAAAACTTGGTTGCTGGAGTTCAGTCAGATTTTTC
TTTTGCTCAAATTTATCGAGTTCAGCCTATTGATCGCATTCGATTGATGCGGACGGGGGTTCCAGCTCGATACATCAATG
TCATCGCTGATTCTATGGGCATTACAAAAGATACCTTATTTAGGTATTTGAATTTACCTAGATCAACTGTGGACAAGAAG
TTAGCTGCAAGTCAAATATTACCTATTGAGCAAGGTGAGCGTTTGATTGGTATGGCTAAGCTTGTTGGACAGGTCGAGTC
AATGATTGCTGAGTCAGGAAACCCAGATGGTTTTGACGCTGCCAAGTGGGTAGCGAGTTGGCTTGAAAAACCATCTCCAG
CTTTAGGTGGCGAGAAGCCATCGGCCTACTTAGATACGATTTCTGGCCAGGAAATGATTTCCGATCTTCTTGCCAAAATT
CAAACTGGGGCATACGCATGA
ATGTCTAGTGTCATCGCCAAAAAGCCCGGCACAAAAGTGACTCGCAAAAACTTGGTTGCTGGAGTTCAGTCAGATTTTTC
TTTTGCTCAAATTTATCGAGTTCAGCCTATTGATCGCATTCGATTGATGCGGACGGGGGTTCCAGCTCGATACATCAATG
TCATCGCTGATTCTATGGGCATTACAAAAGATACCTTATTTAGGTATTTGAATTTACCTAGATCAACTGTGGACAAGAAG
TTAGCTGCAAGTCAAATATTACCTATTGAGCAAGGTGAGCGTTTGATTGGTATGGCTAAGCTTGTTGGACAGGTCGAGTC
AATGATTGCTGAGTCAGGAAACCCAGATGGTTTTGACGCTGCCAAGTGGGTAGCGAGTTGGCTTGAAAAACCATCTCCAG
CTTTAGGTGGCGAGAAGCCATCGGCCTACTTAGATACGATTTCTGGCCAGGAAATGATTTCCGATCTTCTTGCCAAAATT
CAAACTGGGGCATACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|