Detailed information of TA system TA240648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 953060..953574
• Replicon: chromosome
• Accession: NZ_CP094846
• Organism: Ornithobacterium rhinotracheale strain K223

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MT996_RS04440
• Protein ID: WP_153827922.1
• Coordinates: 953317..953574 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MT996_RS04435
• Protein ID: WP_153827923.1
• Coordinates: 953060..953314 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT996_RS04420 (MT996_04420)	948241..949371	+	1131	WP_153827926.1	imelysin family protein	-
MT996_RS04425 (MT996_04425)	949398..950765	+	1368	WP_153827925.1	HTTM domain-containing protein	-
MT996_RS04430 (MT996_04430)	950746..952977	+	2232	WP_153827924.1	TonB-dependent receptor	-
MT996_RS04435 (MT996_04435)	953060..953314	+	255	WP_153827923.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MT996_RS04440 (MT996_04440)	953317..953574	+	258	WP_153827922.1	Txe/YoeB family addiction module toxin	Toxin
MT996_RS04445 (MT996_04445)	953633..953926	-	294	WP_153827921.1	chaperone modulator CbpM	-
MT996_RS04450 (MT996_04450)	953931..954860	-	930	WP_153827920.1	J domain-containing protein	-
MT996_RS04455 (MT996_04455)	954913..955686	-	774	WP_153827919.1	nucleoside triphosphate pyrophosphohydrolase	-
MT996_RS04460 (MT996_04460)	956255..956791	-	537	WP_243910150.1	hypothetical protein	-
MT996_RS04465 (MT996_04465)	956860..957066	+	207	WP_153851815.1	hypothetical protein	-
MT996_RS04470 (MT996_04470)	957069..957623	+	555	WP_153829435.1	Rha family transcriptional regulator	-
MT996_RS04475 (MT996_04475)	957699..957911	-	213	WP_153829434.1	hypothetical protein	-
MT996_RS04480 (MT996_04480)	958020..958169	+	150	WP_185148130.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10674.25 Da
• Isoelectric Point: 9.5405

>T240648 WP_153827922.1 NZ_CP094846:953317-953574 [Ornithobacterium rhinotracheale]
MKYIFVDESWEDYLYWQKNDKRKLKRINALLKDISRTPFESIGKPEPLKHKYSGFWSRRIDDEHRLIYRYEEDKILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T240648 NZ_LT605585:c1901279-1900875 [Brucella inopinata]
TTGAGCAAGCTTTACATGCTGGACACCAACATCGTGTCGGATCTTGCTCGTAACCCTCATGGCCCTGTAGCAAAACATAT
CGCTCGCGTGGGGGCTGATGCGATTTGCGTAAGCATCATTACCGCCTGCGAACTGCGTTACGGTTGTGCGAAAAAGGGTT
CGCCAAGACTGCTCGCACAGATAGAGGCAATACTGGATAGCATTGAAATTCTGCCGCTCGATGTTCCTGCCGATACGGAG
TATGGGGGCATACGGGCAGAACTGGAAGCTGATGGCAAGCCTATCGGTCCCAATGACTTTCTTATCGCGGCTCACGCTTA
CGCACTCGGTGCGGTTCTGGTTACGGCCAATGTCGGTGAGTTTACCCGCATCCGTAAACTTGCTGTCGAAAACTGGTTGA
ATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9601.99 Da
• Isoelectric Point: 6.3404

>AT240648 WP_153827923.1 NZ_CP094846:953060-953314 [Ornithobacterium rhinotracheale]
MLVTNISEFRKDLKSYLNKVAKNFETLIINRGKESAIVVLSLDEYNSLMATNYELSSRKNEQRLDAAIVKLKSGDSFEKT
LIED

Nucleotide

• Length: 255 bp

>AT240648 NZ_LT605585:c1901545-1901276 [Brucella inopinata]
ATGGCACACGCAAGACGTATCGAGCCAACGCCTGCGCGCGAGGCAAAGCTTTTTCGCAACAATAAGAGTCAGGCAGTTCG
TATTCCGGCTGATTTTGAGTTTCCGGGGAACCGTGTGCTTATCCATCGTGAAGGGGACAAGCTCATCATCGAACCTGTTC
GCCGAAAGAATCTGCTCGAAGTTCTGGCAGGATTAAAGCCACTTGGACCAGAGGACGCTTTCCCGGACATTGATGATACA
GCCCTTCCGCTTAAGGATGTAGACCTTTGA