Detailed information of TA system TA240647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1527654..1528168
• Replicon: chromosome
• Accession: NZ_CP094845
• Organism: Ornithobacterium rhinotracheale strain 97

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I4A110
• Locus tag: MT999_RS07480
• Protein ID: WP_014791206.1
• Coordinates: 1527654..1527911 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4A109
• Locus tag: MT999_RS07485
• Protein ID: WP_014791205.1
• Coordinates: 1527914..1528168 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT999_RS07440 (MT999_07440)	1522709..1523536	+	828	WP_014791214.1	50S ribosomal protein L11 methyltransferase	-
MT999_RS07445 (MT999_07445)	1523540..1523833	+	294	WP_014791213.1	ATP-dependent Clp protease adaptor ClpS	-
MT999_RS07450 (MT999_07450)	1523848..1524261	+	414	WP_155814511.1	Holliday junction resolvase RuvX	-
MT999_RS07455 (MT999_07455)	1524412..1524984	+	573	WP_014791211.1	peptide deformylase	-
MT999_RS07460 (MT999_07460)	1525034..1525459	+	426	WP_014791210.1	DUF5606 domain-containing protein	-
MT999_RS07465 (MT999_07465)	1525548..1526321	+	774	WP_014791209.1	nucleoside triphosphate pyrophosphohydrolase	-
MT999_RS07470 (MT999_07470)	1526373..1527299	+	927	WP_014791208.1	J domain-containing protein	-
MT999_RS07475 (MT999_07475)	1527305..1527598	+	294	WP_014791207.1	chaperone modulator CbpM	-
MT999_RS07480 (MT999_07480)	1527654..1527911	-	258	WP_014791206.1	Txe/YoeB family addiction module toxin	Toxin
MT999_RS07485 (MT999_07485)	1527914..1528168	-	255	WP_014791205.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MT999_RS07490 (MT999_07490)	1528239..1530470	-	2232	WP_014791204.1	TonB-dependent receptor	-
MT999_RS07495 (MT999_07495)	1530451..1531818	-	1368	WP_014791203.1	HTTM domain-containing protein	-
MT999_RS07500 (MT999_07500)	1531845..1532972	-	1128	WP_014791202.1	imelysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10592.16 Da
• Isoelectric Point: 8.4443

>T240647 WP_014791206.1 NZ_CP094845:c1527911-1527654 [Ornithobacterium rhinotracheale]
MKYIFVDESWEDYLYWQKDDKRKLKRINALLKDISRTPFEGIGKPEPLKHKYSGFWSRRIDDEHCLIYRYEEDKILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T240647 NZ_LT605059:c3501437-3501048 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAATTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAATTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9587.97 Da
• Isoelectric Point: 6.3475

>AT240647 WP_014791205.1 NZ_CP094845:c1528168-1527914 [Ornithobacterium rhinotracheale]
MLVTNISEFRKDLKSYLNKVAKNFETLIINRGKESAIVVLSLDEYNSLMATNYELSSRKNEQRLDAAIAKLKSGESFEKT
LIED

Nucleotide

• Length: 255 bp

>AT240647 NZ_LT605059:c3501701-3501444 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
TACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: I4A110

Antitoxin

• AlphaFold DB: I4A109