Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 34319..35058 Replicon plasmid pEL-ars1
Accession NZ_CP094842
Organism Enterobacter ludwigii strain Sb-9

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MT488_RS23535 Protein ID WP_148577034.1
Coordinates 34573..35058 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MT488_RS23530 Protein ID WP_127851259.1
Coordinates 34319..34585 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT488_RS23510 (29997) 29997..30694 + 698 WP_094106546.1 IS1 family transposase -
MT488_RS23515 (30820) 30820..31587 + 768 WP_148577037.1 TraX family protein -
MT488_RS23520 (31609) 31609..31839 - 231 WP_148577036.1 DUF2767 family protein -
MT488_RS23525 (32684) 32684..33697 - 1014 WP_148577035.1 plasmid replication initiator RepA -
MT488_RS23530 (34319) 34319..34585 + 267 WP_127851259.1 DUF1778 domain-containing protein Antitoxin
MT488_RS23535 (34573) 34573..35058 + 486 WP_148577034.1 GNAT family N-acetyltransferase Toxin
MT488_RS23540 (35266) 35266..36611 + 1346 Protein_37 ISNCY family transposase -
MT488_RS23545 (36706) 36706..36933 - 228 Protein_38 transposase -
MT488_RS23550 (37215) 37215..37811 - 597 Protein_39 IS3-like element ISEc52 family transposase -
MT488_RS23555 (37799) 37799..37879 + 81 Protein_40 hypothetical protein -
MT488_RS23560 (37876) 37876..39027 + 1152 WP_001254932.1 IS30-like element IS30 family transposase -
MT488_RS23565 (39040) 39040..39249 - 210 Protein_42 transposase -
MT488_RS23570 (39750) 39750..40022 - 273 WP_000019951.1 Ni(II)/Co(II)-binding transcriptional repressor RcnR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-10 - 1..145699 145699
- flank IS/Tn - - 30191..30694 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17764.58 Da        Isoelectric Point: 10.1380

>T240644 WP_148577034.1 NZ_CP094842:34573-35058 [Enterobacter ludwigii]
VGRVTVPEPLSSFHQLAEFVSGEVVLDDWLKQRGLKNQALGAARTFVVCKKNTKQVAGFYSLATGSVNHAEATGSLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEARSFYLHHGFKLSQTQERTLFLKLP
Q

Download         Length: 486 bp

>T240644 NZ_LT604072:3582336-3582593 [Xanthomonas translucens pv. translucens DSM 18974]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACGGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTCTACAAGGTCGAGGCGGGCGTCCTACTGATCGCGCAGGTG
CGGTATCACTACGCGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10065.45 Da        Isoelectric Point: 4.4733

>AT240644 WP_127851259.1 NZ_CP094842:34319-34585 [Enterobacter ludwigii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSNDAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT240644 NZ_LT604072:3582088-3582339 [Xanthomonas translucens pv. translucens DSM 18974]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGTGTCGTCAACAATCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTAGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References