Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-PHA01976
Location 14007..14635 Replicon plasmid unnamed2
Accession NZ_CP094830
Organism Acuticoccus sp. I52.16.1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MRB58_RS23750 Protein ID WP_244782241.1
Coordinates 14384..14635 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MRB58_RS23745 Protein ID WP_244782240.1
Coordinates 14007..14387 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRB58_RS23725 (MRB58_23725) 9746..10513 + 768 WP_244782236.1 ABC transporter ATP-binding protein -
MRB58_RS23730 (MRB58_23730) 10513..11160 + 648 WP_244782237.1 ATP-binding cassette domain-containing protein -
MRB58_RS23735 (MRB58_23735) 11165..12214 - 1050 WP_244782238.1 replication initiator protein A -
MRB58_RS23740 (MRB58_23740) 12595..13911 - 1317 WP_244782239.1 Gfo/Idh/MocA family oxidoreductase -
MRB58_RS23745 (MRB58_23745) 14007..14387 - 381 WP_244782240.1 helix-turn-helix transcriptional regulator Antitoxin
MRB58_RS23750 (MRB58_23750) 14384..14635 - 252 WP_244782241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRB58_RS23755 (MRB58_23755) 14705..16318 - 1614 WP_244782242.1 serine hydrolase -
MRB58_RS23760 (MRB58_23760) 16449..16736 - 288 WP_244782243.1 hypothetical protein -
MRB58_RS23765 (MRB58_23765) 16720..17397 - 678 WP_244782244.1 ParA family protein -
MRB58_RS23770 (MRB58_23770) 17940..18656 - 717 WP_244782245.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40080 40080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(65-119)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9496.00 Da        Isoelectric Point: 11.0304

>T240632 WP_244782241.1 NZ_CP094830:c14635-14384 [Acuticoccus sp. I52.16.1]
MKTVTYLRDARRTLGRMPRTDRERIVAKIEQYARDPASLANNVRTLTGTAFLRLRVGDWRVIMSDEGEVLIIVKVGSRGS
VYE

Download         Length: 252 bp

>T240632 NZ_LT601384:c3537844-3537548 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13597.36 Da        Isoelectric Point: 4.5478

>AT240632 WP_244782240.1 NZ_CP094830:c14387-14007 [Acuticoccus sp. I52.16.1]
MNKSVSDAMEMVSIPRAEYERLRTLAEDHADIVEADQALAALRRGEDVALPGEFARRLFDGESPLKVFREFRGLSGSALA
ERSGVNRVQILDIEAGRSVGSVATLAKLARALDVTIDDLVPDTAAS

Download         Length: 381 bp

>AT240632 NZ_LT601384:c3537546-3537151 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References