Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 2657..3318 Replicon plasmid unnamed1
Accession NZ_CP094829
Organism Acuticoccus sp. I52.16.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MRB58_RS22985 Protein ID WP_244782154.1
Coordinates 2657..3064 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MRB58_RS22990 Protein ID WP_244782155.1
Coordinates 3061..3318 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRB58_RS22970 (MRB58_22970) 370..657 + 288 WP_244782151.1 hypothetical protein -
MRB58_RS22975 (MRB58_22975) 716..1378 - 663 WP_244782152.1 SMC-Scp complex subunit ScpB -
MRB58_RS22980 (MRB58_22980) 1382..2320 - 939 WP_244782153.1 DUF1403 family protein -
MRB58_RS22985 (MRB58_22985) 2657..3064 - 408 WP_244782154.1 type II toxin-antitoxin system VapC family toxin Toxin
MRB58_RS22990 (MRB58_22990) 3061..3318 - 258 WP_244782155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MRB58_RS22995 (MRB58_22995) 3665..4756 + 1092 WP_244782156.1 tyrosine-type recombinase/integrase -
MRB58_RS23000 (MRB58_23000) 5023..6105 + 1083 WP_244782157.1 IS630 family transposase -
MRB58_RS23005 (MRB58_23005) 6418..6747 + 330 Protein_8 transposase -
MRB58_RS23010 (MRB58_23010) 6878..6979 + 102 Protein_9 IS5/IS1182 family transposase -
MRB58_RS23015 (MRB58_23015) 7191..7274 + 84 Protein_10 type II toxin-antitoxin system RelE/ParE family toxin -
MRB58_RS23020 (MRB58_23020) 7306..7455 + 150 Protein_11 TRAP transporter large permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..123782 123782
- flank IS/Tn - - 5023..6105 1082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-56)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14722.83 Da        Isoelectric Point: 6.7273

>T240631 WP_244782154.1 NZ_CP094829:c3064-2657 [Acuticoccus sp. I52.16.1]
VTGVLLDTNVISELTKLNRNPQVVAYLDTLEDGFISVITLHELRYGLERLGDGTRRRTLTETVERFLSLYQDRVLPVGVP
EARAAAALRAGQAQRGRTLHLADALIAATALVHGLTLATRNLGFGVALYSPWGED

Download         Length: 408 bp

>T240631 NZ_LT601384:3455407-3455781 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACTGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9908.27 Da        Isoelectric Point: 8.7926

>AT240631 WP_244782155.1 NZ_CP094829:c3318-3061 [Acuticoccus sp. I52.16.1]
MTHIWTIAEAKARLSEVLRRAGEEGPQRIGTRRGYMVVSEAEWQRLQAPRQRLGHWLVQNWPQLGELELPSRIEPPRPNP
FDEPS

Download         Length: 258 bp

>AT240631 NZ_LT601384:3454986-3455360 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References