Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1757218..1757732 Replicon chromosome
Accession NZ_CP094825
Organism Staphylococcus ureilyticus strain IVB6236

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA21_RS08720 Protein ID WP_262561090.1
Coordinates 1757218..1757424 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA21_RS08725 Protein ID WP_107526320.1
Coordinates 1757439..1757732 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA21_RS08700 (MUA21_08670) 1752668..1754023 - 1356 WP_107526323.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA21_RS08705 (MUA21_08675) 1754036..1755106 - 1071 WP_262561088.1 D-alanine--D-alanine ligase -
MUA21_RS08710 (MUA21_08680) 1755366..1756553 + 1188 WP_262561089.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA21_RS08715 (MUA21_08685) 1756820..1756960 - 141 WP_099091318.1 Lmo0850 family protein -
MUA21_RS08720 (MUA21_08690) 1757218..1757424 - 207 WP_262561090.1 heavy metal-associated domain-containing protein Toxin
MUA21_RS08725 (MUA21_08695) 1757439..1757732 - 294 WP_107526320.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA21_RS08730 (MUA21_08700) 1757873..1759357 + 1485 WP_046207774.1 cardiolipin synthase -
MUA21_RS08735 (MUA21_08705) 1759635..1760279 + 645 WP_262561092.1 HD domain-containing protein -
MUA21_RS08740 (MUA21_08710) 1760479..1761348 - 870 WP_046207772.1 membrane protein insertase YidC -
MUA21_RS08745 (MUA21_08715) 1761435..1762073 - 639 WP_262561093.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7959.06 Da        Isoelectric Point: 4.3611

>T240629 WP_262561090.1 NZ_CP094825:c1757424-1757218 [Staphylococcus ureilyticus]
MESQTIYLRKIDNKQDKLQIERTLSQIIGVNHVSVEIEKGQVFIEFETPASLNNLEKDLYDLGFEILY

Download         Length: 207 bp

>T240629 NZ_LT601384:c3189859-3189524 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11215.87 Da        Isoelectric Point: 6.4780

>AT240629 WP_107526320.1 NZ_CP094825:c1757732-1757439 [Staphylococcus ureilyticus]
MAEMQKAHHSEEIKSNLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp

>AT240629 NZ_LT601384:c3190107-3189859 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References