240627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2371611..2372402 Replicon chromosome
Accession NZ_CP094824
Organism Mammaliicoccus sciuri strain IVB6216

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA60_RS12420 Protein ID WP_262641733.1
Coordinates 2371938..2372402 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA60_RS12415 Protein ID WP_262641732.1
Coordinates 2371611..2371925 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA60_RS12355 (MUA60_12315) 2366806..2367075 - 270 WP_262648444.1 hypothetical protein -
MUA60_RS12360 (MUA60_12320) 2367078..2367338 - 261 WP_262648445.1 hypothetical protein -
MUA60_RS12365 (MUA60_12325) 2367431..2367628 - 198 WP_262648446.1 hypothetical protein -
MUA60_RS12370 (MUA60_12330) 2367750..2368301 + 552 WP_262648447.1 hypothetical protein -
MUA60_RS12375 (MUA60_12335) 2368461..2368637 - 177 WP_262648448.1 hypothetical protein -
MUA60_RS12380 (MUA60_12340) 2368638..2368850 - 213 WP_206180412.1 hypothetical protein -
MUA60_RS12385 (MUA60_12345) 2369220..2369594 + 375 WP_262648449.1 hypothetical protein -
MUA60_RS12390 (MUA60_12350) 2369591..2369791 - 201 WP_262648450.1 hypothetical protein -
MUA60_RS12395 (MUA60_12355) 2369877..2370257 + 381 WP_218697269.1 DUF2513 domain-containing protein -
MUA60_RS12400 (MUA60_12360) 2370244..2370438 - 195 WP_218697268.1 hypothetical protein -
MUA60_RS12405 (MUA60_12365) 2370459..2371205 - 747 WP_262641731.1 phage antirepressor KilAC domain-containing protein -
MUA60_RS12410 (MUA60_12370) 2371221..2371457 - 237 WP_262619693.1 helix-turn-helix transcriptional regulator -
MUA60_RS12415 (MUA60_12375) 2371611..2371925 + 315 WP_262641732.1 helix-turn-helix transcriptional regulator Antitoxin
MUA60_RS12420 (MUA60_12380) 2371938..2372402 + 465 WP_262641733.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA60_RS12425 (MUA60_12385) 2372417..2373001 + 585 WP_262641735.1 DUF4352 domain-containing protein -
MUA60_RS12430 (MUA60_12390) 2373049..2373360 + 312 WP_262641736.1 S24 family peptidase -
MUA60_RS12435 (MUA60_12395) 2373375..2373686 + 312 WP_262641737.1 hypothetical protein -
MUA60_RS12440 (MUA60_12400) 2373722..2373904 + 183 WP_242449798.1 hypothetical protein -
MUA60_RS12445 (MUA60_12405) 2374111..2374995 + 885 WP_262641738.1 hypothetical protein -
MUA60_RS12450 (MUA60_12410) 2374983..2375174 - 192 WP_262641739.1 hypothetical protein -
MUA60_RS12455 (MUA60_12415) 2375544..2376197 + 654 WP_262641740.1 CPBP family intramembrane metalloprotease -
MUA60_RS12460 (MUA60_12420) 2376264..2377313 + 1050 WP_262641741.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - clpP 2253699..2443926 190227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18245.74 Da        Isoelectric Point: 5.8235

>T240627 WP_262641733.1 NZ_CP094824:2371938-2372402 [Mammaliicoccus sciuri]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE

Download         Length: 465 bp

>T240627 NZ_LT601384:c2972178-2971780 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGAGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12104.62 Da        Isoelectric Point: 7.1663

>AT240627 WP_262641732.1 NZ_CP094824:2371611-2371925 [Mammaliicoccus sciuri]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK

Download         Length: 315 bp

>AT240627 NZ_LT601384:c2972474-2972181 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References