Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1150863..1151613 Replicon chromosome
Accession NZ_CP094824
Organism Mammaliicoccus sciuri strain IVB6216

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA60_RS06035 Protein ID WP_224658872.1
Coordinates 1151467..1151613 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA60_RS06030 Protein ID WP_262650238.1
Coordinates 1150863..1151462 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA60_RS06005 (MUA60_06000) 1146546..1147307 + 762 WP_107577217.1 acetylglutamate kinase -
MUA60_RS06010 (MUA60_06005) 1147798..1148925 + 1128 WP_037589731.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA60_RS06015 (MUA60_06010) 1148929..1149402 + 474 WP_025904798.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA60_RS06020 (MUA60_06015) 1149437..1149577 - 141 WP_162841915.1 hypothetical protein -
MUA60_RS06025 (MUA60_06020) 1149664..1150803 + 1140 WP_262650236.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA60_RS06030 (MUA60_06025) 1150863..1151462 + 600 WP_262650238.1 glucosamine-6-phosphate isomerase Antitoxin
MUA60_RS06035 (MUA60_06030) 1151467..1151613 + 147 WP_224658872.1 SAS053 family protein Toxin
MUA60_RS06040 (MUA60_06035) 1151767..1153155 + 1389 WP_262650240.1 class II fumarate hydratase -
MUA60_RS06045 (MUA60_06040) 1153245..1154771 + 1527 WP_262650241.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5713.12 Da        Isoelectric Point: 3.8403

>T240626 WP_224658872.1 NZ_CP094824:1151467-1151613 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Download         Length: 147 bp

>T240626 NZ_LT601384:c2913740-2913372 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCTCCGGCGGCGAAGCCCTGTCCGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTTTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATTG
ATGCCAGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGCAATGGATTT
AACTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGTTGATGAGCCGGTG
TTCTTACAGAGATGTAAGTAATATTGTTCTTAGCCGATCACGGTTGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22321.18 Da        Isoelectric Point: 4.8551

>AT240626 WP_262650238.1 NZ_CP094824:1150863-1151462 [Mammaliicoccus sciuri]
MTLNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT240626 NZ_LT601384:c2914066-2913761 [Escherichia coli]
CTGGTGGGGCTACCCTACACCGTGACGCCCTGTTCTGGCACCCGTCTGGTGCAGGAGGGCAACCGACTGTACTATTTGGC
TGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGCTGGATGTCGTATTTCCACATTTTATCAGTC
AGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGTTTCACCCTGTACCACAACGGTTTCACC
TGCGAAGCCGATACCCTTGGTAGTTGCGGCTATGTATACATCGCCATTTATCCCACTCAGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References