Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 915345..915884 Replicon chromosome
Accession NZ_CP094824
Organism Mammaliicoccus sciuri strain IVB6216

Toxin (Protein)


Gene name mazF Uniprot ID A0A8E2VFW5
Locus tag MUA60_RS04650 Protein ID WP_025904511.1
Coordinates 915513..915884 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA60_RS04645 Protein ID WP_048540868.1
Coordinates 915345..915512 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA60_RS04620 (MUA60_04620) 911228..911707 + 480 WP_262649971.1 PH domain-containing protein -
MUA60_RS04625 (MUA60_04625) 911697..913217 + 1521 WP_262649973.1 PH domain-containing protein -
MUA60_RS04630 (MUA60_04630) 913207..913671 + 465 WP_262649975.1 PH domain-containing protein -
MUA60_RS04635 (MUA60_04635) 913702..914064 + 363 WP_103361832.1 holo-ACP synthase -
MUA60_RS04640 (MUA60_04640) 914112..915260 + 1149 WP_262649978.1 alanine racemase -
MUA60_RS04645 (MUA60_04645) 915345..915512 + 168 WP_048540868.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA60_RS04650 (MUA60_04650) 915513..915884 + 372 WP_025904511.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA60_RS04655 (MUA60_04655) 915981..916985 + 1005 WP_262649980.1 PP2C family protein-serine/threonine phosphatase -
MUA60_RS04660 (MUA60_04660) 917090..917413 + 324 WP_025904513.1 anti-sigma factor antagonist -
MUA60_RS04665 (MUA60_04665) 917418..917894 + 477 WP_025904514.1 anti-sigma B factor RsbW -
MUA60_RS04670 (MUA60_04670) 917869..918639 + 771 WP_262649982.1 RNA polymerase sigma factor SigB -
MUA60_RS04675 (MUA60_04675) 918803..920047 - 1245 WP_262648674.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13641.78 Da        Isoelectric Point: 9.9193

>T240625 WP_025904511.1 NZ_CP094824:915513-915884 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T240625 NZ_LT601384:2719062-2719280 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT240625 WP_048540868.1 NZ_CP094824:915345-915512 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp

>AT240625 NZ_LT601384:2718662-2719036 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References