Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1155968..1156718 Replicon chromosome
Accession NZ_CP094823
Organism Mammaliicoccus sciuri strain IVB6217

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA76_RS05790 Protein ID WP_224658872.1
Coordinates 1156572..1156718 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA76_RS05785 Protein ID WP_164960896.1
Coordinates 1155968..1156567 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA76_RS05760 (MUA76_05755) 1151611..1152372 + 762 WP_262651599.1 acetylglutamate kinase -
MUA76_RS05765 (MUA76_05760) 1152902..1154029 + 1128 WP_262651600.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA76_RS05770 (MUA76_05765) 1154033..1154506 + 474 WP_025904798.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA76_RS05775 (MUA76_05770) 1154541..1154681 - 141 WP_162841915.1 hypothetical protein -
MUA76_RS05780 (MUA76_05775) 1154768..1155919 + 1152 WP_049320870.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA76_RS05785 (MUA76_05780) 1155968..1156567 + 600 WP_164960896.1 glucosamine-6-phosphate isomerase Antitoxin
MUA76_RS05790 (MUA76_05785) 1156572..1156718 + 147 WP_224658872.1 SAS053 family protein Toxin
MUA76_RS05795 (MUA76_05790) 1156871..1158259 + 1389 WP_049320873.1 class II fumarate hydratase -
MUA76_RS05800 (MUA76_05795) 1158348..1159873 + 1526 Protein_1114 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5713.12 Da        Isoelectric Point: 3.8403

>T240623 WP_224658872.1 NZ_CP094823:1156572-1156718 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Download         Length: 147 bp

>T240623 NZ_LT601384:c2125356-2124973 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22325.18 Da        Isoelectric Point: 4.8551

>AT240623 WP_164960896.1 NZ_CP094823:1155968-1156567 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELFDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT240623 NZ_LT601384:c2125817-2125437 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References