Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 973502..974041 Replicon chromosome
Accession NZ_CP094823
Organism Mammaliicoccus sciuri strain IVB6217

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag MUA76_RS04745 Protein ID WP_048540867.1
Coordinates 973670..974041 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag MUA76_RS04740 Protein ID WP_025904510.1
Coordinates 973502..973669 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA76_RS04715 (MUA76_04710) 969384..969863 + 480 WP_262651542.1 PH domain-containing protein -
MUA76_RS04720 (MUA76_04715) 969853..971373 + 1521 WP_049320126.1 PH domain-containing protein -
MUA76_RS04725 (MUA76_04720) 971363..971827 + 465 WP_049320129.1 PH domain-containing protein -
MUA76_RS04730 (MUA76_04725) 971859..972221 + 363 WP_049320130.1 holo-ACP synthase -
MUA76_RS04735 (MUA76_04730) 972269..973417 + 1149 WP_049320131.1 alanine racemase -
MUA76_RS04740 (MUA76_04735) 973502..973669 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA76_RS04745 (MUA76_04740) 973670..974041 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA76_RS04750 (MUA76_04745) 974138..975142 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
MUA76_RS04755 (MUA76_04750) 975247..975570 + 324 WP_025904513.1 anti-sigma factor antagonist -
MUA76_RS04760 (MUA76_04755) 975575..976051 + 477 WP_025904514.1 anti-sigma B factor RsbW -
MUA76_RS04765 (MUA76_04760) 976026..976796 + 771 WP_049320132.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T240622 WP_048540867.1 NZ_CP094823:973670-974041 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T240622 NZ_LT601384:c1914267-1913890 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT240622 WP_025904510.1 NZ_CP094823:973502-973669 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT240622 NZ_LT601384:c1914688-1914314 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGTGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References