Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 2231953..2232744 | Replicon | chromosome |
| Accession | NZ_CP094822 | ||
| Organism | Mammaliicoccus sciuri strain IVB6223 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA96_RS11315 | Protein ID | WP_262641733.1 |
| Coordinates | 2232280..2232744 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA96_RS11310 | Protein ID | WP_262641732.1 |
| Coordinates | 2231953..2232267 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA96_RS11230 (MUA96_11220) | 2226998..2227537 | - | 540 | WP_262641719.1 | host-nuclease inhibitor Gam family protein | - |
| MUA96_RS11235 (MUA96_11225) | 2227530..2227799 | - | 270 | WP_262641720.1 | hypothetical protein | - |
| MUA96_RS11240 (MUA96_11230) | 2227802..2228062 | - | 261 | WP_262641721.1 | hypothetical protein | - |
| MUA96_RS11245 (MUA96_11235) | 2228155..2228352 | - | 198 | WP_262641722.1 | hypothetical protein | - |
| MUA96_RS11250 (MUA96_11240) | 2228349..2228621 | - | 273 | WP_262641723.1 | hypothetical protein | - |
| MUA96_RS11255 (MUA96_11245) | 2228622..2228864 | - | 243 | WP_262641724.1 | hypothetical protein | - |
| MUA96_RS11260 (MUA96_11250) | 2228937..2229176 | + | 240 | WP_262641725.1 | DUF1883 domain-containing protein | - |
| MUA96_RS11265 (MUA96_11255) | 2229205..2229360 | - | 156 | WP_262641726.1 | hypothetical protein | - |
| MUA96_RS11270 (MUA96_11260) | 2229361..2229516 | - | 156 | WP_262641728.1 | hypothetical protein | - |
| MUA96_RS11275 (MUA96_11265) | 2229517..2229729 | - | 213 | WP_206180412.1 | hypothetical protein | - |
| MUA96_RS11280 (MUA96_11270) | 2229786..2230025 | + | 240 | WP_262641729.1 | hypothetical protein | - |
| MUA96_RS11285 (MUA96_11275) | 2229973..2230170 | - | 198 | WP_262641730.1 | hypothetical protein | - |
| MUA96_RS11290 (MUA96_11280) | 2230219..2230599 | + | 381 | WP_218697269.1 | DUF2513 domain-containing protein | - |
| MUA96_RS11295 (MUA96_11285) | 2230586..2230780 | - | 195 | WP_218697268.1 | hypothetical protein | - |
| MUA96_RS11300 (MUA96_11290) | 2230801..2231547 | - | 747 | WP_262641731.1 | phage antirepressor KilAC domain-containing protein | - |
| MUA96_RS11305 (MUA96_11295) | 2231563..2231799 | - | 237 | WP_262619693.1 | helix-turn-helix transcriptional regulator | - |
| MUA96_RS11310 (MUA96_11300) | 2231953..2232267 | + | 315 | WP_262641732.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA96_RS11315 (MUA96_11305) | 2232280..2232744 | + | 465 | WP_262641733.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| MUA96_RS11320 (MUA96_11310) | 2232759..2233343 | + | 585 | WP_262641735.1 | DUF4352 domain-containing protein | - |
| MUA96_RS11325 (MUA96_11315) | 2233391..2233702 | + | 312 | WP_262641736.1 | S24 family peptidase | - |
| MUA96_RS11330 (MUA96_11320) | 2233717..2234028 | + | 312 | WP_262641737.1 | hypothetical protein | - |
| MUA96_RS11335 (MUA96_11325) | 2234064..2234246 | + | 183 | WP_242449798.1 | hypothetical protein | - |
| MUA96_RS11340 (MUA96_11330) | 2234453..2235337 | + | 885 | WP_262641738.1 | hypothetical protein | - |
| MUA96_RS11345 (MUA96_11335) | 2235325..2235516 | - | 192 | WP_262641739.1 | hypothetical protein | - |
| MUA96_RS11350 (MUA96_11340) | 2235886..2236539 | + | 654 | WP_262641740.1 | CPBP family intramembrane metalloprotease | - |
| MUA96_RS11355 (MUA96_11345) | 2236606..2237655 | + | 1050 | WP_262641741.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2165355..2240967 | 75612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18245.74 Da Isoelectric Point: 5.8235
>T240620 WP_262641733.1 NZ_CP094822:2232280-2232744 [Mammaliicoccus sciuri]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE
Download Length: 465 bp
>T240620 NZ_LT601384:1731574-1731681 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12104.62 Da Isoelectric Point: 7.1663
>AT240620 WP_262641732.1 NZ_CP094822:2231953-2232267 [Mammaliicoccus sciuri]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK
Download Length: 315 bp
>AT240620 NZ_LT601384:c1731524-1731461 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|