Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2190550..2191341 Replicon chromosome
Accession NZ_CP094821
Organism Mammaliicoccus sciuri strain IVB6224

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA49_RS11055 Protein ID WP_262641733.1
Coordinates 2190877..2191341 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA49_RS11050 Protein ID WP_262641732.1
Coordinates 2190550..2190864 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA49_RS10970 (MUA49_10965) 2185595..2186134 - 540 WP_262641719.1 host-nuclease inhibitor Gam family protein -
MUA49_RS10975 (MUA49_10970) 2186127..2186396 - 270 WP_262641720.1 hypothetical protein -
MUA49_RS10980 (MUA49_10975) 2186399..2186659 - 261 WP_262641721.1 hypothetical protein -
MUA49_RS10985 (MUA49_10980) 2186752..2186949 - 198 WP_262641722.1 hypothetical protein -
MUA49_RS10990 (MUA49_10985) 2186946..2187218 - 273 WP_262641723.1 hypothetical protein -
MUA49_RS10995 (MUA49_10990) 2187219..2187461 - 243 WP_262641724.1 hypothetical protein -
MUA49_RS11000 (MUA49_10995) 2187534..2187773 + 240 WP_262641725.1 DUF1883 domain-containing protein -
MUA49_RS11005 (MUA49_11000) 2187802..2187957 - 156 WP_262641726.1 hypothetical protein -
MUA49_RS11010 (MUA49_11005) 2187958..2188113 - 156 WP_262641728.1 hypothetical protein -
MUA49_RS11015 (MUA49_11010) 2188114..2188326 - 213 WP_206180412.1 hypothetical protein -
MUA49_RS11020 (MUA49_11015) 2188383..2188622 + 240 WP_262641729.1 hypothetical protein -
MUA49_RS11025 (MUA49_11020) 2188570..2188767 - 198 WP_262641730.1 hypothetical protein -
MUA49_RS11030 (MUA49_11025) 2188816..2189196 + 381 WP_218697269.1 DUF2513 domain-containing protein -
MUA49_RS11035 (MUA49_11030) 2189183..2189377 - 195 WP_218697268.1 hypothetical protein -
MUA49_RS11040 (MUA49_11035) 2189398..2190144 - 747 WP_262641731.1 phage antirepressor KilAC domain-containing protein -
MUA49_RS11045 (MUA49_11040) 2190160..2190396 - 237 WP_262619693.1 helix-turn-helix transcriptional regulator -
MUA49_RS11050 (MUA49_11045) 2190550..2190864 + 315 WP_262641732.1 helix-turn-helix transcriptional regulator Antitoxin
MUA49_RS11055 (MUA49_11050) 2190877..2191341 + 465 WP_262641733.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA49_RS11060 (MUA49_11055) 2191356..2191940 + 585 WP_262641735.1 DUF4352 domain-containing protein -
MUA49_RS11065 (MUA49_11060) 2191988..2192299 + 312 WP_262641736.1 S24 family peptidase -
MUA49_RS11070 (MUA49_11065) 2192314..2192625 + 312 WP_262641737.1 hypothetical protein -
MUA49_RS11075 (MUA49_11070) 2192661..2192843 + 183 WP_242449798.1 hypothetical protein -
MUA49_RS11080 (MUA49_11075) 2193050..2193934 + 885 WP_262641738.1 hypothetical protein -
MUA49_RS11085 (MUA49_11080) 2193922..2194113 - 192 WP_262641739.1 hypothetical protein -
MUA49_RS11090 (MUA49_11085) 2194483..2195136 + 654 WP_262641740.1 CPBP family intramembrane metalloprotease -
MUA49_RS11095 (MUA49_11090) 2195203..2196252 + 1050 WP_262641741.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2123952..2199564 75612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18245.74 Da        Isoelectric Point: 5.8235

>T240616 WP_262641733.1 NZ_CP094821:2190877-2191341 [Mammaliicoccus sciuri]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE

Download         Length: 465 bp

>T240616 NZ_LT601384:1057321-1057424 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12104.62 Da        Isoelectric Point: 7.1663

>AT240616 WP_262641732.1 NZ_CP094821:2190550-2190864 [Mammaliicoccus sciuri]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK

Download         Length: 315 bp

>AT240616 NZ_LT601384:c1057462-1057191 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References