240612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2232358..2233149 Replicon chromosome
Accession NZ_CP094820
Organism Mammaliicoccus sciuri strain IVB6225

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA89_RS11330 Protein ID WP_262641733.1
Coordinates 2232685..2233149 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA89_RS11325 Protein ID WP_262641732.1
Coordinates 2232358..2232672 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA89_RS11245 (MUA89_11235) 2227403..2227942 - 540 WP_262641719.1 host-nuclease inhibitor Gam family protein -
MUA89_RS11250 (MUA89_11240) 2227935..2228204 - 270 WP_262641720.1 hypothetical protein -
MUA89_RS11255 (MUA89_11245) 2228207..2228467 - 261 WP_262641721.1 hypothetical protein -
MUA89_RS11260 (MUA89_11250) 2228560..2228757 - 198 WP_262641722.1 hypothetical protein -
MUA89_RS11265 (MUA89_11255) 2228754..2229026 - 273 WP_262641723.1 hypothetical protein -
MUA89_RS11270 (MUA89_11260) 2229027..2229269 - 243 WP_262641724.1 hypothetical protein -
MUA89_RS11275 (MUA89_11265) 2229342..2229581 + 240 WP_262641725.1 DUF1883 domain-containing protein -
MUA89_RS11280 (MUA89_11270) 2229610..2229765 - 156 WP_262641726.1 hypothetical protein -
MUA89_RS11285 (MUA89_11275) 2229766..2229921 - 156 WP_262641728.1 hypothetical protein -
MUA89_RS11290 (MUA89_11280) 2229922..2230134 - 213 WP_206180412.1 hypothetical protein -
MUA89_RS11295 (MUA89_11285) 2230191..2230430 + 240 WP_262641729.1 hypothetical protein -
MUA89_RS11300 (MUA89_11290) 2230378..2230575 - 198 WP_262641730.1 hypothetical protein -
MUA89_RS11305 (MUA89_11295) 2230624..2231004 + 381 WP_218697269.1 DUF2513 domain-containing protein -
MUA89_RS11310 (MUA89_11300) 2230991..2231185 - 195 WP_218697268.1 hypothetical protein -
MUA89_RS11315 (MUA89_11305) 2231206..2231952 - 747 WP_262641731.1 phage antirepressor KilAC domain-containing protein -
MUA89_RS11320 (MUA89_11310) 2231968..2232204 - 237 WP_262619693.1 helix-turn-helix transcriptional regulator -
MUA89_RS11325 (MUA89_11315) 2232358..2232672 + 315 WP_262641732.1 helix-turn-helix transcriptional regulator Antitoxin
MUA89_RS11330 (MUA89_11320) 2232685..2233149 + 465 WP_262641733.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA89_RS11335 (MUA89_11325) 2233164..2233748 + 585 WP_262641735.1 DUF4352 domain-containing protein -
MUA89_RS11340 (MUA89_11330) 2233796..2234107 + 312 WP_262641736.1 S24 family peptidase -
MUA89_RS11345 (MUA89_11335) 2234122..2234433 + 312 WP_262641737.1 hypothetical protein -
MUA89_RS11350 (MUA89_11340) 2234469..2234651 + 183 WP_242449798.1 hypothetical protein -
MUA89_RS11355 (MUA89_11345) 2234858..2235742 + 885 WP_262641738.1 hypothetical protein -
MUA89_RS11360 (MUA89_11350) 2235730..2235921 - 192 WP_262641739.1 hypothetical protein -
MUA89_RS11365 (MUA89_11355) 2236291..2236944 + 654 WP_262641740.1 CPBP family intramembrane metalloprotease -
MUA89_RS11370 (MUA89_11360) 2237011..2238060 + 1050 WP_262641741.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2165760..2241372 75612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18245.74 Da        Isoelectric Point: 5.8235

>T240612 WP_262641733.1 NZ_CP094820:2232685-2233149 [Mammaliicoccus sciuri]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE

Download         Length: 465 bp

>T240612 NZ_LT599047:c2204866-2204684 [Brucella sp. 10RB9215]
ATGGAGCGAGACAGCAAAAAAATAGTAAAAAGGCTAAAAAGCGAGGGGTTTGAATTGATATCGGTGAGGGGTTCTCACCA
TAAATTCAGAAAAGGGGATAAAACAGTGATTGTTCCCCACCCCAAAAAAGACCTACCGCAAGGCACGGCAAGGTCAATCG
CAGAACAAGCGGGCTGGATATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12104.62 Da        Isoelectric Point: 7.1663

>AT240612 WP_262641732.1 NZ_CP094820:2232358-2232672 [Mammaliicoccus sciuri]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK

Download         Length: 315 bp

>AT240612 NZ_LT599047:c2204623-2204225 [Brucella sp. 10RB9215]
ATGAAACACTACTTTGCTTTAGTGCACAAAGACGACGATAGCGCGTATGGTGTCCAGTTTCCAGACATTCCCGGCGTGTT
TTCGGCTGCGGATGAAATCAATGATATAATTAAGGAGGCGGTCGAGGCGTTGCAGCTTTACGCCGAAGATGCCGAGTTGC
CTGCAGCTTCATCCCATGCGGAAATCATCGTGCGTGATGATGTCAAGGCGGAGTTGGCAAAGGGAGCCTTCTTGATCTCG
GTTCCTTATATCGAAGACGACTCCGCCGTTGTCCGTGCAAATATTTCGTTTGAACGTGGTATTCTGAAAGCGATTGATGC
GACGGCGAAAGCACGCGGCTTAAGCCGTTCCGGGTTTCTGGCGCAAGCGGCCAGGCACGAAATCGAAGCCGGTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References