Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1026666..1027416 Replicon chromosome
Accession NZ_CP094819
Organism Mammaliicoccus sciuri strain IVB6228

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA42_RS05215 Protein ID WP_224658872.1
Coordinates 1027270..1027416 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA42_RS05210 Protein ID WP_262643003.1
Coordinates 1026666..1027265 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA42_RS05185 (MUA42_05195) 1021907..1022668 + 762 WP_262642999.1 acetylglutamate kinase -
MUA42_RS05190 (MUA42_05200) 1023600..1024727 + 1128 WP_262643001.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA42_RS05195 (MUA42_05205) 1024731..1025204 + 474 WP_025904798.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA42_RS05200 (MUA42_05210) 1025239..1025379 - 141 WP_162841915.1 hypothetical protein -
MUA42_RS05205 (MUA42_05215) 1025466..1026617 + 1152 WP_262643002.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA42_RS05210 (MUA42_05220) 1026666..1027265 + 600 WP_262643003.1 glucosamine-6-phosphate isomerase Antitoxin
MUA42_RS05215 (MUA42_05225) 1027270..1027416 + 147 WP_224658872.1 SAS053 family protein Toxin
MUA42_RS05220 (MUA42_05230) 1027570..1028958 + 1389 WP_262643005.1 class II fumarate hydratase -
MUA42_RS05225 (MUA42_05235) 1029048..1030574 + 1527 WP_262643007.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5713.12 Da        Isoelectric Point: 3.8403

>T240607 WP_224658872.1 NZ_CP094819:1027270-1027416 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Download         Length: 147 bp

>T240607 NZ_LT598688:c2212559-2212350 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22321.18 Da        Isoelectric Point: 4.8551

>AT240607 WP_262643003.1 NZ_CP094819:1026666-1027265 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYTADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT240607 NZ_LT598688:c2212864-2212571 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References