240606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 799297..799836 Replicon chromosome
Accession NZ_CP094819
Organism Mammaliicoccus sciuri strain IVB6228

Toxin (Protein)


Gene name mazF Uniprot ID A0A8E2VFW5
Locus tag MUA42_RS03875 Protein ID WP_025904511.1
Coordinates 799465..799836 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA42_RS03870 Protein ID WP_048540868.1
Coordinates 799297..799464 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA42_RS03845 (MUA42_03850) 795180..795659 + 480 WP_262642750.1 PH domain-containing protein -
MUA42_RS03850 (MUA42_03855) 795649..797169 + 1521 WP_262642751.1 PH domain-containing protein -
MUA42_RS03855 (MUA42_03860) 797159..797623 + 465 WP_262642752.1 PH domain-containing protein -
MUA42_RS03860 (MUA42_03865) 797654..798016 + 363 WP_262642753.1 holo-ACP synthase -
MUA42_RS03865 (MUA42_03870) 798064..799212 + 1149 WP_262642754.1 alanine racemase -
MUA42_RS03870 (MUA42_03875) 799297..799464 + 168 WP_048540868.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA42_RS03875 (MUA42_03880) 799465..799836 + 372 WP_025904511.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA42_RS03880 (MUA42_03885) 799933..800937 + 1005 WP_262642755.1 PP2C family protein-serine/threonine phosphatase -
MUA42_RS03885 (MUA42_03890) 801042..801365 + 324 WP_025904513.1 anti-sigma factor antagonist -
MUA42_RS03890 (MUA42_03895) 801370..801846 + 477 WP_025904514.1 anti-sigma B factor RsbW -
MUA42_RS03895 (MUA42_03900) 801821..802591 + 771 WP_025904515.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13641.78 Da        Isoelectric Point: 9.9193

>T240606 WP_025904511.1 NZ_CP094819:799465-799836 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T240606 NZ_LT598688:c2192955-2192593 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT240606 WP_048540868.1 NZ_CP094819:799297-799464 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp

>AT240606 NZ_LT598688:c2193122-2192952 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References