Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 2190549..2191340 | Replicon | chromosome |
| Accession | NZ_CP094818 | ||
| Organism | Mammaliicoccus sciuri strain IVB6229 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA77_RS11045 | Protein ID | WP_262641733.1 |
| Coordinates | 2190876..2191340 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA77_RS11040 | Protein ID | WP_262641732.1 |
| Coordinates | 2190549..2190863 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA77_RS10960 (MUA77_10960) | 2185594..2186133 | - | 540 | WP_262641719.1 | host-nuclease inhibitor Gam family protein | - |
| MUA77_RS10965 (MUA77_10965) | 2186126..2186395 | - | 270 | WP_262641720.1 | hypothetical protein | - |
| MUA77_RS10970 (MUA77_10970) | 2186398..2186658 | - | 261 | WP_262641721.1 | hypothetical protein | - |
| MUA77_RS10975 (MUA77_10975) | 2186751..2186948 | - | 198 | WP_262641722.1 | hypothetical protein | - |
| MUA77_RS10980 (MUA77_10980) | 2186945..2187217 | - | 273 | WP_262641723.1 | hypothetical protein | - |
| MUA77_RS10985 (MUA77_10985) | 2187218..2187460 | - | 243 | WP_262641724.1 | hypothetical protein | - |
| MUA77_RS10990 (MUA77_10990) | 2187533..2187772 | + | 240 | WP_262641725.1 | DUF1883 domain-containing protein | - |
| MUA77_RS10995 (MUA77_10995) | 2187801..2187956 | - | 156 | WP_262641726.1 | hypothetical protein | - |
| MUA77_RS11000 (MUA77_11000) | 2187957..2188112 | - | 156 | WP_262641728.1 | hypothetical protein | - |
| MUA77_RS11005 (MUA77_11005) | 2188113..2188325 | - | 213 | WP_206180412.1 | hypothetical protein | - |
| MUA77_RS11010 (MUA77_11010) | 2188382..2188621 | + | 240 | WP_262641729.1 | hypothetical protein | - |
| MUA77_RS11015 (MUA77_11015) | 2188569..2188766 | - | 198 | WP_262641730.1 | hypothetical protein | - |
| MUA77_RS11020 (MUA77_11020) | 2188815..2189195 | + | 381 | WP_218697269.1 | DUF2513 domain-containing protein | - |
| MUA77_RS11025 (MUA77_11025) | 2189182..2189376 | - | 195 | WP_218697268.1 | hypothetical protein | - |
| MUA77_RS11030 (MUA77_11030) | 2189397..2190143 | - | 747 | WP_262641731.1 | phage antirepressor KilAC domain-containing protein | - |
| MUA77_RS11035 (MUA77_11035) | 2190159..2190395 | - | 237 | WP_262619693.1 | helix-turn-helix transcriptional regulator | - |
| MUA77_RS11040 (MUA77_11040) | 2190549..2190863 | + | 315 | WP_262641732.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA77_RS11045 (MUA77_11045) | 2190876..2191340 | + | 465 | WP_262641733.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| MUA77_RS11050 (MUA77_11050) | 2191355..2191939 | + | 585 | WP_262641735.1 | DUF4352 domain-containing protein | - |
| MUA77_RS11055 (MUA77_11055) | 2191987..2192298 | + | 312 | WP_262641736.1 | S24 family peptidase | - |
| MUA77_RS11060 (MUA77_11060) | 2192313..2192624 | + | 312 | WP_262641737.1 | hypothetical protein | - |
| MUA77_RS11065 (MUA77_11065) | 2192660..2192842 | + | 183 | WP_242449798.1 | hypothetical protein | - |
| MUA77_RS11070 (MUA77_11070) | 2193049..2193933 | + | 885 | WP_262641738.1 | hypothetical protein | - |
| MUA77_RS11075 (MUA77_11075) | 2193921..2194112 | - | 192 | WP_262641739.1 | hypothetical protein | - |
| MUA77_RS11080 (MUA77_11080) | 2194482..2195135 | + | 654 | WP_262641740.1 | CPBP family intramembrane metalloprotease | - |
| MUA77_RS11085 (MUA77_11085) | 2195202..2196251 | + | 1050 | WP_262641741.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2123951..2199563 | 75612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18245.74 Da Isoelectric Point: 5.8235
>T240604 WP_262641733.1 NZ_CP094818:2190876-2191340 [Mammaliicoccus sciuri]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKAKYGLSTYHKGYVIKFDPLQVFKHIEFE
Download Length: 465 bp
>T240604 NZ_LT598688:c2094083-2093907 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12104.62 Da Isoelectric Point: 7.1663
>AT240604 WP_262641732.1 NZ_CP094818:2190549-2190863 [Mammaliicoccus sciuri]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDEDNDEVQHRAAHL
EGNLTDDEWKRVLDYADYIRSRRK
Download Length: 315 bp
>AT240604 NZ_LT598688:2093784-2093839 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|