Detailed information of TA system TA240600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1058604..1059354
• Replicon: chromosome
• Accession: NZ_CP094817
• Organism: Mammaliicoccus sciuri strain IVB6230

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA27_RS05300
• Protein ID: WP_224658872.1
• Coordinates: 1059208..1059354 (+)
• Length: 49 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: MUA27_RS05295
• Protein ID: WP_025904800.1
• Coordinates: 1058604..1059203 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA27_RS05270 (MUA27_05265)	1054247..1055008	+	762	WP_096791765.1	acetylglutamate kinase	-
MUA27_RS05275 (MUA27_05270)	1055538..1056665	+	1128	WP_096791766.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA27_RS05280 (MUA27_05275)	1056669..1057142	+	474	WP_025904798.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA27_RS05285 (MUA27_05280)	1057177..1057317	-	141	WP_162841915.1	hypothetical protein	-
MUA27_RS05290 (MUA27_05285)	1057404..1058555	+	1152	WP_096791767.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA27_RS05295 (MUA27_05290)	1058604..1059203	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA27_RS05300 (MUA27_05295)	1059208..1059354	+	147	WP_224658872.1	SAS053 family protein	Toxin
MUA27_RS05305 (MUA27_05300)	1059507..1060895	+	1389	WP_096791768.1	class II fumarate hydratase	-
MUA27_RS05310 (MUA27_05305)	1060984..1062510	+	1527	WP_096791769.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5713.12 Da
• Isoelectric Point: 3.8403

>T240600 WP_224658872.1 NZ_CP094817:1059208-1059354 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 147 bp

>T240600 NZ_LT598688:c323742-323278 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT240600 WP_025904800.1 NZ_CP094817:1058604-1059203 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT240600 NZ_LT598688:c324069-323755 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATTTA
GAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6