Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 876232..876771 Replicon chromosome
Accession NZ_CP094817
Organism Mammaliicoccus sciuri strain IVB6230

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag MUA27_RS04255 Protein ID WP_048540867.1
Coordinates 876400..876771 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag MUA27_RS04250 Protein ID WP_025904510.1
Coordinates 876232..876399 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA27_RS04225 (MUA27_04220) 872114..872593 + 480 WP_058612364.1 PH domain-containing protein -
MUA27_RS04230 (MUA27_04225) 872583..874103 + 1521 WP_058612363.1 PH domain-containing protein -
MUA27_RS04235 (MUA27_04230) 874093..874557 + 465 WP_058612362.1 PH domain-containing protein -
MUA27_RS04240 (MUA27_04235) 874589..874951 + 363 WP_058591084.1 holo-ACP synthase -
MUA27_RS04245 (MUA27_04240) 874999..876147 + 1149 WP_096792044.1 alanine racemase -
MUA27_RS04250 (MUA27_04245) 876232..876399 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA27_RS04255 (MUA27_04250) 876400..876771 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA27_RS04260 (MUA27_04255) 876868..877872 + 1005 WP_096792045.1 PP2C family protein-serine/threonine phosphatase -
MUA27_RS04265 (MUA27_04260) 877977..878300 + 324 WP_025904513.1 anti-sigma factor antagonist -
MUA27_RS04270 (MUA27_04265) 878305..878781 + 477 WP_025904514.1 anti-sigma B factor RsbW -
MUA27_RS04275 (MUA27_04270) 878756..879526 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T240599 WP_048540867.1 NZ_CP094817:876400-876771 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T240599 NZ_LT598666:48300-48485 [Enterococcus faecium]
ATGCCACTTACGGGAAAAGAAATGCTTAAGTTATTGAAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCA
TCATCTTTATAAGGATGGTGTTAGAATCACTGTTCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCAAAAAA
TTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT240599 WP_025904510.1 NZ_CP094817:876232-876399 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT240599 NZ_LT598666:48519-48950 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGCTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References