Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1036408..1037158 Replicon chromosome
Accession NZ_CP094816
Organism Mammaliicoccus sciuri strain IVB6231

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA23_RS05165 Protein ID WP_224658872.1
Coordinates 1037012..1037158 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA23_RS05160 Protein ID WP_048539838.1
Coordinates 1036408..1037007 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA23_RS05135 (MUA23_05135) 1032011..1032772 + 762 WP_048539835.1 acetylglutamate kinase -
MUA23_RS05140 (MUA23_05140) 1033342..1034469 + 1128 WP_106417549.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA23_RS05145 (MUA23_05145) 1034473..1034946 + 474 WP_025904798.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA23_RS05150 (MUA23_05150) 1034981..1035121 - 141 WP_162841915.1 hypothetical protein -
MUA23_RS05155 (MUA23_05155) 1035208..1036359 + 1152 WP_058591070.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA23_RS05160 (MUA23_05160) 1036408..1037007 + 600 WP_048539838.1 glucosamine-6-phosphate isomerase Antitoxin
MUA23_RS05165 (MUA23_05165) 1037012..1037158 + 147 WP_224658872.1 SAS053 family protein Toxin
MUA23_RS05170 (MUA23_05170) 1037311..1038699 + 1389 WP_048539839.1 class II fumarate hydratase -
MUA23_RS05175 (MUA23_05175) 1038789..1040315 + 1527 WP_208182404.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5713.12 Da        Isoelectric Point: 3.8403

>T240598 WP_224658872.1 NZ_CP094816:1037012-1037158 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Download         Length: 147 bp

>T240598 NZ_LT598663:543952-544293 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22290.17 Da        Isoelectric Point: 4.9758

>AT240598 WP_048539838.1 NZ_CP094816:1036408-1037007 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYNQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT240598 NZ_LT598663:543722-543952 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References