Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1039539..1040289 Replicon chromosome
Accession NZ_CP094815
Organism Mammaliicoccus sciuri strain IVB6255

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA36_RS05185 Protein ID WP_224658872.1
Coordinates 1040143..1040289 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA36_RS05180 Protein ID WP_164960896.1
Coordinates 1039539..1040138 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA36_RS05155 (MUA36_05155) 1035182..1035943 + 762 WP_049320866.1 acetylglutamate kinase -
MUA36_RS05160 (MUA36_05160) 1036473..1037600 + 1128 WP_049320868.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA36_RS05165 (MUA36_05165) 1037604..1038077 + 474 WP_025904798.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA36_RS05170 (MUA36_05170) 1038112..1038252 - 141 WP_162841915.1 hypothetical protein -
MUA36_RS05175 (MUA36_05175) 1038339..1039490 + 1152 WP_049320870.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA36_RS05180 (MUA36_05180) 1039539..1040138 + 600 WP_164960896.1 glucosamine-6-phosphate isomerase Antitoxin
MUA36_RS05185 (MUA36_05185) 1040143..1040289 + 147 WP_224658872.1 SAS053 family protein Toxin
MUA36_RS05190 (MUA36_05190) 1040442..1041830 + 1389 WP_049320873.1 class II fumarate hydratase -
MUA36_RS05195 (MUA36_05195) 1041919..1043445 + 1527 WP_049320874.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5713.12 Da        Isoelectric Point: 3.8403

>T240596 WP_224658872.1 NZ_CP094815:1040143-1040289 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Download         Length: 147 bp

>T240596 NZ_LT598658:c81421-81134 [Legionella pneumophila]
ATGATCTATGAGTTACATTTCCATCCGCTTGCGTTAAAAGAATGGAAGAAACTATCGAAGGAGTTGCAGGAACAGTTTAA
AAAACTATTAAAACGGCGACTGGAAAATCCGCATGTTATTTCTGCCAAACTTAGTGGCCATCTTAAAGATTGCTATAAGA
TAAAATTGCATCAGGCCGGCTATAGATTGGTCTACCAAGTTAACGATAATAAAATGATTCTCCTTGTTGTTGCTGTAGGC
AAGCGAAACAAAAATAAAGTCTATGAGTCAGCAGAAGATAGGACTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22325.18 Da        Isoelectric Point: 4.8551

>AT240596 WP_164960896.1 NZ_CP094815:1039539-1040138 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELFDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT240596 NZ_LT598658:c81662-81411 [Legionella pneumophila]
ATGCAAACTTTATATGCAACACAAGTCGCTAGCATTAGCGAATTAAAGAAAAATCCCACAAAACTTATTAATGATGCTCA
TGGGATGCCCGTGGTGATTCTTAACCATAATGTAGCTGCTGCTTATTTAATTCCAGCAGAAACTTTTGAAAAACTGATGG
ATGCTGTTGACGAAAGCGAGCTAAAAAGCATTGTAGAACAACGCCTTTCAGAGCCCTTTACGCCAGTTAAGGTTGCGCTT
GATGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References