Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 854520..855059 Replicon chromosome
Accession NZ_CP094815
Organism Mammaliicoccus sciuri strain IVB6255

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag MUA36_RS04130 Protein ID WP_048540867.1
Coordinates 854688..855059 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag MUA36_RS04125 Protein ID WP_025904510.1
Coordinates 854520..854687 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA36_RS04100 (MUA36_04100) 850402..850881 + 480 WP_049320124.1 PH domain-containing protein -
MUA36_RS04105 (MUA36_04105) 850871..852391 + 1521 WP_049320126.1 PH domain-containing protein -
MUA36_RS04110 (MUA36_04110) 852381..852845 + 465 WP_049320129.1 PH domain-containing protein -
MUA36_RS04115 (MUA36_04115) 852877..853239 + 363 WP_049320130.1 holo-ACP synthase -
MUA36_RS04120 (MUA36_04120) 853287..854435 + 1149 WP_049320131.1 alanine racemase -
MUA36_RS04125 (MUA36_04125) 854520..854687 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA36_RS04130 (MUA36_04130) 854688..855059 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA36_RS04135 (MUA36_04135) 855156..856160 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
MUA36_RS04140 (MUA36_04140) 856265..856588 + 324 WP_025904513.1 anti-sigma factor antagonist -
MUA36_RS04145 (MUA36_04145) 856593..857069 + 477 WP_025904514.1 anti-sigma B factor RsbW -
MUA36_RS04150 (MUA36_04150) 857044..857814 + 771 WP_049320132.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T240595 WP_048540867.1 NZ_CP094815:854688-855059 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T240595 NZ_LT596222:54118-54417 [Yersinia pseudotuberculosis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT240595 WP_025904510.1 NZ_CP094815:854520-854687 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT240595 NZ_LT596222:53883-54125 [Yersinia pseudotuberculosis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGGTACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References