Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 838262..838786 | Replicon | chromosome |
| Accession | NZ_CP094814 | ||
| Organism | Staphylococcus agnetis strain IVB6175 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A0A8HRS0 |
| Locus tag | MUA52_RS03925 | Protein ID | WP_037567539.1 |
| Coordinates | 838433..838786 (+) | Length | 118 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A7Z7QEK8 |
| Locus tag | MUA52_RS03920 | Protein ID | WP_037567537.1 |
| Coordinates | 838262..838432 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA52_RS03895 (MUA52_03890) | 834056..834532 | + | 477 | WP_262619142.1 | PH domain-containing protein | - |
| MUA52_RS03900 (MUA52_03895) | 834525..836012 | + | 1488 | WP_262619143.1 | PH domain-containing protein | - |
| MUA52_RS03905 (MUA52_03900) | 835993..836502 | + | 510 | WP_262619144.1 | PH domain-containing protein | - |
| MUA52_RS03910 (MUA52_03905) | 836573..836923 | + | 351 | WP_060551516.1 | holo-ACP synthase | - |
| MUA52_RS03915 (MUA52_03910) | 837029..838177 | + | 1149 | WP_262619145.1 | alanine racemase | - |
| MUA52_RS03920 (MUA52_03915) | 838262..838432 | + | 171 | WP_037567537.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| MUA52_RS03925 (MUA52_03920) | 838433..838786 | + | 354 | WP_037567539.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MUA52_RS03930 (MUA52_03925) | 838846..839850 | + | 1005 | WP_262619146.1 | PP2C family protein-serine/threonine phosphatase | - |
| MUA52_RS03935 (MUA52_03930) | 839931..840257 | + | 327 | WP_037567545.1 | anti-sigma factor antagonist | - |
| MUA52_RS03940 (MUA52_03935) | 840260..840739 | + | 480 | WP_037567547.1 | anti-sigma B factor RsbW | - |
| MUA52_RS03945 (MUA52_03940) | 840714..841484 | + | 771 | WP_262619147.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13103.33 Da Isoelectric Point: 10.3729
>T240592 WP_037567539.1 NZ_CP094814:838433-838786 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK
Download Length: 354 bp
>T240592 NZ_LT596221:c2040429-2039971 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6265.89 Da Isoelectric Point: 4.0644
>AT240592 WP_037567537.1 NZ_CP094814:838262-838432 [Staphylococcus agnetis]
MSAFYQTRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD
MSAFYQTRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD
Download Length: 171 bp
>AT240592 NZ_LT596221:c2040988-2040542 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8HRS0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7QEK8 |