Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 975901..976674 Replicon chromosome
Accession NZ_CP094813
Organism Staphylococcus agnetis strain IVB6177

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA84_RS04730 Protein ID WP_164671803.1
Coordinates 976519..976674 (+) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA84_RS04725 Protein ID WP_105996312.1
Coordinates 975901..976500 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA84_RS04705 (MUA84_04700) 972205..972927 + 723 WP_262619230.1 amino acid ABC transporter ATP-binding protein -
MUA84_RS04710 (MUA84_04705) 973099..974226 + 1128 WP_105996309.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA84_RS04715 (MUA84_04710) 974229..974699 + 471 WP_262619232.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA84_RS04720 (MUA84_04715) 974714..975883 + 1170 WP_262619233.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA84_RS04725 (MUA84_04720) 975901..976500 + 600 WP_105996312.1 glucosamine-6-phosphate isomerase Antitoxin
MUA84_RS04730 (MUA84_04725) 976519..976674 + 156 WP_164671803.1 SAS053 family protein Toxin
MUA84_RS04735 (MUA84_04730) 976833..977234 + 402 WP_262619235.1 hypothetical protein -
MUA84_RS04740 (MUA84_04735) 977391..978776 + 1386 WP_262619236.1 class II fumarate hydratase -
MUA84_RS04745 (MUA84_04740) 978798..980324 + 1527 WP_105996314.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6028.39 Da        Isoelectric Point: 3.9242

>T240588 WP_164671803.1 NZ_CP094813:976519-976674 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPDIRSDQ

Download         Length: 156 bp

>T240588 NZ_LT594504:4229524-4229988 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22431.40 Da        Isoelectric Point: 5.6315

>AT240588 WP_105996312.1 NZ_CP094813:975901-976500 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVLDYLKRNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEHKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Download         Length: 600 bp

>AT240588 NZ_LT594504:4229189-4229524 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References