Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 839005..839529 Replicon chromosome
Accession NZ_CP094813
Organism Staphylococcus agnetis strain IVB6177

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag MUA84_RS03930 Protein ID WP_037567539.1
Coordinates 839176..839529 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7Z7QEK8
Locus tag MUA84_RS03925 Protein ID WP_037567537.1
Coordinates 839005..839175 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA84_RS03900 (MUA84_03895) 834799..835275 + 477 WP_262619142.1 PH domain-containing protein -
MUA84_RS03905 (MUA84_03900) 835268..836755 + 1488 WP_262619143.1 PH domain-containing protein -
MUA84_RS03910 (MUA84_03905) 836736..837245 + 510 WP_262619144.1 PH domain-containing protein -
MUA84_RS03915 (MUA84_03910) 837316..837666 + 351 WP_060551516.1 holo-ACP synthase -
MUA84_RS03920 (MUA84_03915) 837772..838920 + 1149 WP_262619145.1 alanine racemase -
MUA84_RS03925 (MUA84_03920) 839005..839175 + 171 WP_037567537.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA84_RS03930 (MUA84_03925) 839176..839529 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA84_RS03935 (MUA84_03930) 839589..840593 + 1005 WP_262619146.1 PP2C family protein-serine/threonine phosphatase -
MUA84_RS03940 (MUA84_03935) 840674..841000 + 327 WP_037567545.1 anti-sigma factor antagonist -
MUA84_RS03945 (MUA84_03940) 841003..841482 + 480 WP_037567547.1 anti-sigma B factor RsbW -
MUA84_RS03950 (MUA84_03945) 841457..842227 + 771 WP_262619147.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T240587 WP_037567539.1 NZ_CP094813:839176-839529 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240587 NZ_LT594504:c4116449-4116153 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6265.89 Da        Isoelectric Point: 4.0644

>AT240587 WP_037567537.1 NZ_CP094813:839005-839175 [Staphylococcus agnetis]
MSAFYQTRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT240587 NZ_LT594504:c4116151-4115756 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7QEK8

References