240583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1842516..1843322 Replicon chromosome
Accession NZ_CP094812
Organism Staphylococcus agnetis strain IVB6186

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA43_RS09105 Protein ID WP_262608359.1
Coordinates 1842858..1843322 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA43_RS09100 Protein ID WP_262608358.1
Coordinates 1842516..1842845 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA43_RS09040 (MUA43_09025) 1837727..1838125 - 399 WP_262608348.1 single-stranded DNA-binding protein -
MUA43_RS09045 (MUA43_09030) 1838125..1838748 - 624 WP_262608349.1 ERF family protein -
MUA43_RS09050 (MUA43_09035) 1838745..1838963 - 219 WP_252591708.1 DUF2483 family protein -
MUA43_RS09055 (MUA43_09040) 1838960..1839229 - 270 WP_037572060.1 hypothetical protein -
MUA43_RS09060 (MUA43_09045) 1839309..1839482 - 174 WP_262608350.1 hypothetical protein -
MUA43_RS09065 (MUA43_09050) 1839476..1839688 - 213 WP_262608351.1 hypothetical protein -
MUA43_RS09070 (MUA43_09055) 1839842..1840165 + 324 WP_262608352.1 hypothetical protein -
MUA43_RS09075 (MUA43_09060) 1840154..1840321 - 168 WP_262608353.1 hypothetical protein -
MUA43_RS09080 (MUA43_09065) 1840334..1841083 - 750 WP_262608354.1 phage antirepressor KilAC domain-containing protein -
MUA43_RS09085 (MUA43_09070) 1841083..1841271 - 189 WP_262608355.1 helix-turn-helix transcriptional regulator -
MUA43_RS09090 (MUA43_09075) 1841624..1842067 - 444 WP_262608356.1 hypothetical protein -
MUA43_RS09095 (MUA43_09080) 1842079..1842324 - 246 WP_262608357.1 helix-turn-helix transcriptional regulator -
MUA43_RS09100 (MUA43_09085) 1842516..1842845 + 330 WP_262608358.1 helix-turn-helix transcriptional regulator Antitoxin
MUA43_RS09105 (MUA43_09090) 1842858..1843322 + 465 WP_262608359.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA43_RS09110 (MUA43_09095) 1843338..1843874 + 537 WP_262608360.1 Ltp family lipoprotein -
MUA43_RS09115 (MUA43_09100) 1844384..1844620 + 237 WP_262608906.1 hypothetical protein -
MUA43_RS09120 (MUA43_09105) 1844642..1845418 + 777 WP_262608361.1 DUF1828 domain-containing protein -
MUA43_RS09125 (MUA43_09110) 1845483..1846532 + 1050 WP_262608362.1 site-specific integrase -
MUA43_RS09140 (MUA43_09125) 1846905..1847315 - 411 WP_103345470.1 YolD-like family protein -
MUA43_RS09145 (MUA43_09130) 1847748..1848197 - 450 WP_060552462.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1804418..1848450 44032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18313.82 Da        Isoelectric Point: 6.2308

>T240583 WP_262608359.1 NZ_CP094812:1842858-1843322 [Staphylococcus agnetis]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPERKKVEVLFEELAHNKLTYGDITDQKQFNNRKFENYAR
RYSYETSMPLSGIVKAFKQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLSTFNEGHLIQFEPLRVFKYKNYQ

Download         Length: 465 bp

>T240583 NZ_LT594504:c3720611-3720300 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12742.43 Da        Isoelectric Point: 9.3985

>AT240583 WP_262608358.1 NZ_CP094812:1842516-1842845 [Staphylococcus agnetis]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQKQPQH
RAAHLEGELTDDEWQRVLEYADYIRSKRK

Download         Length: 330 bp

>AT240583 NZ_LT594504:c3720303-3719884 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References