Detailed information of TA system TA240582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 977052..977825
• Replicon: chromosome
• Accession: NZ_CP094812
• Organism: Staphylococcus agnetis strain IVB6186

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA43_RS04780
• Protein ID: WP_165804964.1
• Coordinates: 977670..977825 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A242VDN1
• Locus tag: MUA43_RS04775
• Protein ID: WP_060551399.1
• Coordinates: 977052..977651 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA43_RS04755 (MUA43_04745)	973355..974077	+	723	WP_107368902.1	amino acid ABC transporter ATP-binding protein	-
MUA43_RS04760 (MUA43_04750)	974250..975377	+	1128	WP_145051498.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA43_RS04765 (MUA43_04755)	975380..975850	+	471	WP_060551401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA43_RS04770 (MUA43_04760)	975865..977034	+	1170	WP_103346439.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA43_RS04775 (MUA43_04765)	977052..977651	+	600	WP_060551399.1	hypothetical protein	Antitoxin
MUA43_RS04780 (MUA43_04770)	977670..977825	+	156	WP_165804964.1	SAS053 family protein	Toxin
MUA43_RS04785 (MUA43_04775)	977984..978385	+	402	WP_060551398.1	hypothetical protein	-
MUA43_RS04790 (MUA43_04780)	978542..979927	+	1386	WP_262608809.1	class II fumarate hydratase	-
MUA43_RS04795 (MUA43_04785)	979949..981475	+	1527	WP_262608810.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6027.40 Da
• Isoelectric Point: 3.9813

>T240582 WP_165804964.1 NZ_CP094812:977670-977825 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPNIRSDQ

Nucleotide

• Length: 156 bp

>T240582 NZ_LT594504:c3488756-3488358 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22437.36 Da
• Isoelectric Point: 5.3398

>AT240582 WP_060551399.1 NZ_CP094812:977052-977651 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVFDYLKHNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEQKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT240582 NZ_LT594504:c3488983-3488756 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A242VDN1