240581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 839612..840136 Replicon chromosome
Accession NZ_CP094812
Organism Staphylococcus agnetis strain IVB6186

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag MUA43_RS03980 Protein ID WP_037567539.1
Coordinates 839783..840136 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A242VEK4
Locus tag MUA43_RS03975 Protein ID WP_060551514.1
Coordinates 839612..839782 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA43_RS03950 (MUA43_03940) 835405..835881 + 477 WP_060551519.1 PH domain-containing protein -
MUA43_RS03955 (MUA43_03945) 835874..837361 + 1488 WP_060551518.1 PH domain-containing protein -
MUA43_RS03960 (MUA43_03950) 837345..837851 + 507 WP_157951749.1 PH domain-containing protein -
MUA43_RS03965 (MUA43_03955) 837923..838273 + 351 WP_060551516.1 holo-ACP synthase -
MUA43_RS03970 (MUA43_03960) 838379..839527 + 1149 WP_262608782.1 alanine racemase -
MUA43_RS03975 (MUA43_03965) 839612..839782 + 171 WP_060551514.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA43_RS03980 (MUA43_03970) 839783..840136 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA43_RS03985 (MUA43_03975) 840196..841200 + 1005 WP_060551513.1 PP2C family protein-serine/threonine phosphatase -
MUA43_RS03990 (MUA43_03980) 841281..841607 + 327 WP_037567545.1 anti-sigma factor antagonist -
MUA43_RS03995 (MUA43_03985) 841610..842089 + 480 WP_262608783.1 anti-sigma B factor RsbW -
MUA43_RS04000 (MUA43_03990) 842064..842834 + 771 WP_060551512.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T240581 WP_037567539.1 NZ_CP094812:839783-840136 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240581 NZ_LT594504:c2992578-2992327 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT240581 WP_060551514.1 NZ_CP094812:839612-839782 [Staphylococcus agnetis]
MSAFYQIRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT240581 NZ_LT594504:c2992330-2992076 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A242VEK4

References