Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1842509..1843315 | Replicon | chromosome |
| Accession | NZ_CP094811 | ||
| Organism | Staphylococcus agnetis strain IVB6187 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA97_RS09105 | Protein ID | WP_262608359.1 |
| Coordinates | 1842851..1843315 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA97_RS09100 | Protein ID | WP_262608358.1 |
| Coordinates | 1842509..1842838 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA97_RS09040 (MUA97_09025) | 1837720..1838118 | - | 399 | WP_262608348.1 | single-stranded DNA-binding protein | - |
| MUA97_RS09045 (MUA97_09030) | 1838118..1838741 | - | 624 | WP_262608349.1 | ERF family protein | - |
| MUA97_RS09050 (MUA97_09035) | 1838738..1838956 | - | 219 | WP_252591708.1 | DUF2483 family protein | - |
| MUA97_RS09055 (MUA97_09040) | 1838953..1839222 | - | 270 | WP_037572060.1 | hypothetical protein | - |
| MUA97_RS09060 (MUA97_09045) | 1839302..1839475 | - | 174 | WP_262608350.1 | hypothetical protein | - |
| MUA97_RS09065 (MUA97_09050) | 1839469..1839681 | - | 213 | WP_262608351.1 | hypothetical protein | - |
| MUA97_RS09070 (MUA97_09055) | 1839835..1840158 | + | 324 | WP_262608352.1 | hypothetical protein | - |
| MUA97_RS09075 (MUA97_09060) | 1840147..1840314 | - | 168 | WP_262608353.1 | hypothetical protein | - |
| MUA97_RS09080 (MUA97_09065) | 1840327..1841076 | - | 750 | WP_262608354.1 | phage antirepressor KilAC domain-containing protein | - |
| MUA97_RS09085 (MUA97_09070) | 1841076..1841264 | - | 189 | WP_262608355.1 | helix-turn-helix transcriptional regulator | - |
| MUA97_RS09090 (MUA97_09075) | 1841617..1842060 | - | 444 | WP_262608356.1 | hypothetical protein | - |
| MUA97_RS09095 (MUA97_09080) | 1842072..1842317 | - | 246 | WP_262608357.1 | helix-turn-helix transcriptional regulator | - |
| MUA97_RS09100 (MUA97_09085) | 1842509..1842838 | + | 330 | WP_262608358.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA97_RS09105 (MUA97_09090) | 1842851..1843315 | + | 465 | WP_262608359.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| MUA97_RS09110 (MUA97_09095) | 1843331..1843867 | + | 537 | WP_262608360.1 | Ltp family lipoprotein | - |
| MUA97_RS09115 (MUA97_09100) | 1844377..1844613 | + | 237 | WP_262608906.1 | hypothetical protein | - |
| MUA97_RS09120 (MUA97_09105) | 1844635..1845411 | + | 777 | WP_262608361.1 | DUF1828 domain-containing protein | - |
| MUA97_RS09125 (MUA97_09110) | 1845476..1846525 | + | 1050 | WP_262608362.1 | site-specific integrase | - |
| MUA97_RS09140 (MUA97_09125) | 1846898..1847308 | - | 411 | WP_103345470.1 | YolD-like family protein | - |
| MUA97_RS09145 (MUA97_09130) | 1847741..1848190 | - | 450 | WP_060552462.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1804411..1848443 | 44032 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18313.82 Da Isoelectric Point: 6.2308
>T240577 WP_262608359.1 NZ_CP094811:1842851-1843315 [Staphylococcus agnetis]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPERKKVEVLFEELAHNKLTYGDITDQKQFNNRKFENYAR
RYSYETSMPLSGIVKAFKQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLSTFNEGHLIQFEPLRVFKYKNYQ
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPERKKVEVLFEELAHNKLTYGDITDQKQFNNRKFENYAR
RYSYETSMPLSGIVKAFKQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLSTFNEGHLIQFEPLRVFKYKNYQ
Download Length: 465 bp
>T240577 NZ_LT594504:c2179805-2179698 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12742.43 Da Isoelectric Point: 9.3985
>AT240577 WP_262608358.1 NZ_CP094811:1842509-1842838 [Staphylococcus agnetis]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQKQPQH
RAAHLEGELTDDEWQRVLEYADYIRSKRK
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQKQPQH
RAAHLEGELTDDEWQRVLEYADYIRSKRK
Download Length: 330 bp
>AT240577 NZ_LT594504:2179852-2179918 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|