Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 977045..977818 Replicon chromosome
Accession NZ_CP094811
Organism Staphylococcus agnetis strain IVB6187

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA97_RS04780 Protein ID WP_165804964.1
Coordinates 977663..977818 (+) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A242VDN1
Locus tag MUA97_RS04775 Protein ID WP_060551399.1
Coordinates 977045..977644 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA97_RS04755 (MUA97_04745) 973348..974070 + 723 WP_107368902.1 amino acid ABC transporter ATP-binding protein -
MUA97_RS04760 (MUA97_04750) 974243..975370 + 1128 WP_145051498.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA97_RS04765 (MUA97_04755) 975373..975843 + 471 WP_060551401.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA97_RS04770 (MUA97_04760) 975858..977027 + 1170 WP_103346439.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA97_RS04775 (MUA97_04765) 977045..977644 + 600 WP_060551399.1 hypothetical protein Antitoxin
MUA97_RS04780 (MUA97_04770) 977663..977818 + 156 WP_165804964.1 SAS053 family protein Toxin
MUA97_RS04785 (MUA97_04775) 977977..978378 + 402 WP_060551398.1 hypothetical protein -
MUA97_RS04790 (MUA97_04780) 978535..979920 + 1386 WP_262608809.1 class II fumarate hydratase -
MUA97_RS04795 (MUA97_04785) 979942..981468 + 1527 WP_262608810.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(135-197)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6027.40 Da        Isoelectric Point: 3.9813

>T240576 WP_165804964.1 NZ_CP094811:977663-977818 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPNIRSDQ

Download         Length: 156 bp

>T240576 NZ_LT594504:c2179269-2179162 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22437.36 Da        Isoelectric Point: 5.3398

>AT240576 WP_060551399.1 NZ_CP094811:977045-977644 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVFDYLKHNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEQKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Download         Length: 600 bp

>AT240576 NZ_LT594504:2179322-2179383 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A242VDN1

References